About a third of heart disease patients undergoing angioplasty to open up blocked arteries develop complications and even new blockages caused by stents-the tiny metal scaffolds inserted to hold the arteries open. Now researchers at the Children’s Hospital of Philadelphia have developed a way to shield arteries from such complications using the stents themselves to deliver beneficial genes to the body. In contrast to other methods of gene therapy, which use viruses as carriers, this new approach depends on coating the stents with a biodegradable polymer containing therapeutic genes. In recent experiments, researchers inserted the coated stents into pigs’ arteries and observed the polymer degrade, releasing genes into the arterial-wall cells. Once inside the cells, the genes began producing specific proteins. According to head researcher Robert Levy, the team is screening various candidate genes to find one that would not only protect blood vessels but also treat underlying heart disease. They hope to start human clinical trials within three years.
Forget dating apps: Here’s how the net’s newest matchmakers help you find love
Fed up with apps, people looking for romance are finding inspiration on Twitter, TikTok—and even email newsletters.
How AI is reinventing what computers are
Three key ways artificial intelligence is changing what it means to compute.
These weird virtual creatures evolve their bodies to solve problems
They show how intelligence and body plans are closely linked—and could unlock AI for robots.
We reviewed three at-home covid tests. The results were mixed.
Over-the-counter coronavirus tests are finally available in the US. Some are more accurate and easier to use than others.
Get the latest updates from
MIT Technology Review
Discover special offers, top stories, upcoming events, and more.