A View from Jessica Leber
A DIY Bioprinter Is Born
Members of the biohacker movement have created an inexpensive device to print cells. Will they print a leaf next?
Three-dimensional printers have been used to print iPhone cases, gun parts, even chocolate candies. Now a group of biohackers that meets at BioCurious, a community biology laboratory in Sunnyvale, California, has created a do-it-yourself inkjet printer that can print living cells.
Not everyone is comfortable with the idea of the biohacker movement (see “Doing Biotech in My Bedroom”), whose aim is to tweak everyday technologies and make it affordable and easy for anyone to manipulate DNA, cells, and other of life’s building blocks. The far-fetched possibilities ring too close to bad science fiction. Other skeptics think these bio-tinkerers won’t produce much more than elaborate science fair projects.
And it’s true, the new DIY bioprinter isn’t a fundamental breakthrough—well-funded academic and corporate research labs already work with more sophisticated 3-D printing equipment to layer cells and build artificial tissue structures as they try to engineer entire organs and replacement human parts.
But after a conversation with Patrik D’haeseleer, a bioinformatics researcher at Lawrence Livermore National Laboratory who moonlighted as organizer of the DIY bio-printer project at BioCurious, I saw why it’s important to encourage more people to play around with biology. These hobbyists could one day make important contributions to the biotech field. Apple and Microsoft were born in garages, too.
This DIY bio-printer took some trial-and-error to create. After dismantling an HP 5150 inkjet printer and later deciding to instead build an inkjet platform from scratch, D’haeseleer and other volunteers successfully put together the bio-printer for about $150. Their first model only works in two dimensions—to demonstrate, they printed a sheet of fluorescent E. Coli cells to read “I ♥ BioCurious” over and over again (see video demo).
So what’s it good for? D’haeseleer’s idea is to use the printer to print plant cells and build photosynthetic structures, although this is a long-term project that will be much harder than squirting E. Coli on a sheet. He imagines applications could include creating energy-producing surfaces on everyday objects. But really, D’haeseleer, mostly wants to print a leaf to see if he can do it.
To me it means that even if today’s biotinkerers don’t create the next Microsoft or Apple, they might just spark the curiosity of someone else who will. The BioCurious group has posted a detailed how-to guide to make the bio-printer on the website Instructables.
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June 11-12, 2019