Our editors picked the 50 companies that are smartest about how they combine innovative technology with an effective business model. Some are new companies and startups, while others have continued to reinvent themselves.Learn More
Making advances in cadmium telluride cells; building three of the five largest solar projects in the U.S.
estimated 2017 revenueCompany Details
Continues to tweak its chips, originally developed for gaming, to help develop breakthrough technologies like deep learning and autonomous driving.
spending on R&D to create its new data-center chipCompany Details
Changing the economics of space travel with its successful landing and recycling of rockets to be recycled for multiple trips
price discount being considered for customers who agree to fly their payloads on reused rocketsCompany Details
Vindicated this year when the U.S. FDA granted permission to tell customers whether their DNA puts them at higher risk for some diseases.
number of customers who have consented to have their genetic information used for scientific researchCompany Details
Continues to dominate research into AI while expanding innovation in phone systems, virtual reality, and self-driving cars.
amount of energy the company says it saves applying machine-learning algorithms from its DeepMind subsidiary to cooling its data center.Company Details
Nearing FDA approval of its experimental immunotherapy that uses a patient’s own blood cells to combat cancer.
proportion of study participants very sick with lymphoma who showed no sign of the disease six months after a single treatment with Kite’s therapyCompany Details
Acquisitions in computer vision and AI show it’s serious about adapting to new technology.
portion of revenues derived from areas beyond PC chipsCompany Details
Its solid-state version of lidar is cheaper and more compact than conventional versions of a technology essential to autonomous driving.
price of its S3 Lidar sensors for autonomous vehiclesCompany Details
Minting money selling its popular mobile phones and laptops while adding impressive names to its AI research team and promising to do more manufacturing in the U.S.
cash on its balance sheet, more than the entire market value of General ElectricCompany Details
Its novel 3-D printing process makes it possible to fabricate parts out of a wide variety of plastics.
number of pairs of shoes Adidas will print by the end of 2018 using Carbon technologyCompany Details
RNA drug approved for a rare disease, spinal muscular atrophy
number of its RNA-targeted drugs in developmentCompany Details
After a drop in sales last fall, unveiled a new machine, NovaSeq, that will be capable of sequencing 48 entire human genomes in two and a half days—and could one day push the cost of genome sequencing down to $100.
price of the cheaper of its two NovaSeq modelsCompany Details
Despite controversies over fake news, live streaming video, and discriminatory advertising, and poor sales of its Oculus VR headset, it continues to work on interesting applications of AI and VR, and its Instagram business is singing.
number of natural-language data sets built into the company’s AI research tool, ParlAI.Company Details
Has found a business model for online education by working with corporations to make course material relevant to jobs; now connecting companies to students and graduates, too.
number of “nanodegrees” the company offers in skills for selected jobsCompany Details
Though a startup, it’s got its own fab in the Bay Area and an ambitious approach to quantum computing that combines hardware and software, focusing on design that can be easily commercialized.
venture funding raised by the company in the past yearCompany Details
Combining strengths of humans and robots into exoskeleton suits in a bid to help people and machines work together.
the type of technology the company makes, in which a human controls a robot via a wearable deviceCompany Details
Autopilot accidents, car maintenance problems, and concerns about its solar strategy and ability to produce enough cars have hurt, but cofounder Elon Musk continues to take big bets. Battery cell production has begun at his giant Nevada “gigafactory.”
number of preorders for its lower-cost Model 3Company Details
Looking to push AI-generated tools, such as an algorithm designed to summarize documents, to its massive user base.
market share in customer relationship softwareCompany Details
Though its glasses have not been a runaway hit, Snap was strategically smart to recast itself as a camera company. It’s entertaining users with face-altering filters and pioneering the use of machine vision and augmented reality for socializing.
number of snaps users create each dayCompany Details
With nearly $100 million from VC firms, GE, Alphabet, and others, this startup is focused on cheap, fast 3-D printing of metal parts.
cost of its first product, to begin shipping in SeptemberCompany Details
Its technology can write and rewrite its own code, algorithms that will accelerate machine learning.
its technology’s efficiency advantage over other machine-learning methodsCompany Details
Leading gene-therapy company focuses on engineered T cells that recognize and kill cancer and other conditions. Its treatment for sickle-cell disease appears promising.
increase in stock price over the past yearCompany Details
Moving to incorporate AI into its businesses as it focuses on technological innovation in wind and renewable energy, data-driven services, and other business lines.
number of jet engines GE says will be connected to the Internet by 2020Company Details
Launched by well-regarded researchers and funded with venture capital backed by Chinese and U.S. pharmaceutical companies, it will sequence anyone’s genome for just $1,000 and interpret it, too. In 2017, it started offering to sequence newborns in China.
number of conditions, risks, and traits it will tell parents about in their newbornsCompany Details
In a first, the FDA has approved its immunotherapy Keytruda to treat cancers on the basis of the tumor’s genetic characteristics, not its location in the body.
estimated 2017 revenue, buoyed by sales of KeytrudaCompany Details
The biotech company has a strong drug pipeline and track record treating eye and other diseases, and it’s testing treatments for rheumatoid arthritis, asthma, and pain.
number of U.K. volunteers whose genetic data it is helping sequenceCompany Details
Exploring new technologies like blockchain and cloud AI while continuing work on important long-term challenges like quantum computing.
number of customers the company has worked with on blockchain applicationsCompany Details
Its blindness treatment could be the first gene therapy approved in the U.S. to treat an inherited disease.
estimated number of individuals affected by the disease, Leber hereditary optic neuropathyCompany Details
Headed by an academic from Carnegie Mellon University, the company is still in startup mode but has been garnering attention since last August, when it won the Pentagon’s DARPA contest with a bot designed to autonomously spot, test, and fix software security flaws.
number of previously undiscovered vulnerabilities in networking devices the company’s tools have foundCompany Details
Creating an AI-powered store of the future with Amazon Go while expanding intelligent voice assistant Alexa into phones, cars, and more.
number of programs that software developers have published for AlexaCompany Details
Its fast-growing cloud business has reduced the software giant’s reliance on PC sales. Its expanding team of quantum computing experts hopes to develop commercially viable products to compete with efforts by Google and IBM.
projected annual revenue for its commercial cloud businessCompany Details
Runs the largest online market in Latin America and is expanding to mobile point-of-sale transactions. Its MercadoPago online payment tool lets users deposit cash into their accounts.
number of registered users, a 20 percent increase over the previous yearCompany Details
Its voice assistant technology is the Siri of China, and its real-time portable translator puts AI to remarkable use, overcoming dialect, slang, and background noise to translate between Chinese and a dozen other languages with surprising accuracy.
iFlytek’s share of China’s market in voice-based technologiesCompany Details
Turning its insanely popular chat platform WeChat into a virtual operating system featuring mini programs.
proportion of WeChat’s 770 million daily users who are on the service at least 90 minutes a dayCompany Details
Pioneering new uses of face recognition technology, from fraud investigation to “smile to pay.”
maximum number of points on a person’s face that its technology tracksCompany Details
Has continued to innovate in consumer drones and begun expanding into drones for enterprise as well.
estimated North American market shareCompany Details
Quickly expanding the artificial intelligence in its Alibaba Cloud platform, including industry-specific products, and launching a global electronic trade platform to build its business with small and medium-size companies around the world.
Alibaba’s share of Chinese online commerceCompany Details
Its Alipay business, dominant in China, is moving into new markets with investments in India, Korea, and elsewhere. It’s now exploring AI as a means of underwriting lending, and blockchain to record customers’ charitable donations.
number of annual active usersCompany Details
Despite the high-profile loss this year of its well-regarded head of AI, Andrew Ng, the company is doing important work in the field, including leading China’s National Engineering Lab of Deep Learning Technology and Application.
number of employees dedicated to working on AICompany Details
Overtook General Electric to become the biggest U.S. installer of new wind power last year and is investing in energy storage.
consecutive number of profitable quartersCompany Details
Commercial production at its robot-heavy factory in Ansbach, Germany, is to begin this year, producing locally and on demand. A second factory has been announced in Atlanta.
number of pairs of shoes Adidas makes each year, largely in AsiaCompany Details
Delivering the first run of its short-haul all-electric truck this year while working on vehicle connectivity and autonomous driving for cars.
range of its lithium-battery-powered eTruckCompany Details
Benefiting from the consolidation of India’s competitive e-commerce sector, including $500 million investment from eBay.
company’s current valuation, the highest for any Indian e-commerce startupCompany Details
Its pay-as-you-go solar power model works well in its African target market, and the company is expanding sales with local communications leader Safaricom.
number of homes connected as of this springCompany Details
The online platform has consolidated all its consumer Web services—shopping, travel, food delivery, real estate sales, car rentals—under one name, Jumia.
number of African companies that use Jumia’s platformCompany Details
Evangelists of data-driven medicine are sorting through DNA sequences with AI algorithms to accelerate diagnosis in oncology, cardiology, and more.
number of patients tested to dateCompany Details
Acknowledging the direction of Chinese manufacturing by shifting from low-cost human labor to add extensive robotics to its factories.
number of jobs automation eliminated at a single Chinese factoryCompany Details
Despite some executive turnover and a tough year financially, the company has interesting prospects in virtual reality and access to China’s enthusiastic VR users.
number of pieces of content outside developers have created for its VR system, ViveCompany Details
Twelve years and $200 million in the making, its inexpensive, portable genetic analyzer has been successfully tested from Antarctica to space and shows promising for on-the-spot diagnostic testing, germ monitoring, and more.
record length of a single DNA strand read continuously by one of its machinesCompany Details
Its software helps companies including banks and insurers use AI to do back-office clerical tasks.
number of deals the company signed in 2016, more than four times its 2015 numberCompany Details