Skip to Content
77 Mass Ave

Just-in-Time Pharmacy

System can make small batches of drugs on demand.
June 21, 2016

MIT researchers have developed a compact, portable pharmaceutical manufacturing system that can be reconfigured to produce a variety of drugs on demand. Just as an emergency generator supplies electricity to handle a power outage, this system could be rapidly deployed to produce drugs needed to handle an unexpected disease outbreak, or to prevent a drug shortage caused by a manufacturing plant shutdown.

“Think of this as the emergency backup for pharmaceutical manufacturing,” says Allan Myerson, professor of the practice of chemical engineering and a project leader. “The purpose is not to replace traditional manufacturing; it’s to provide an alternative for these special situations.”

Manufacturing drugs with batch processing, the traditional method, can take weeks or months. Active ingredients are synthesized in chemical manufacturing plants and then shipped to other sites to be converted into a form that can be given to patients, such as tablets, drug solutions, or suspensions. This system offers little flexibility to respond to surges in demand and is susceptible to severe disruption if one of the plants has to shut down.

This machine built by MIT researchers can be reconfigured to manufacture several different drugs, including Benadryl, Valium, and Prozac.

The MIT team built a system that can produce four drugs formulated as solutions or suspensions: Benadryl, lidocaine, Valium, and Prozac. Using this apparatus, the researchers can manufacture about 1,000 doses of a given drug in 24 hours.

Key to the continuous system are new chemical reactions that can occur as the reactants flow through relatively small tubes, much smaller than the huge vats in which most pharmaceutical reactions now take place. Batch processing is limited by the difficulty of cooling these vats, but with the flow system, reactions producing a great deal of heat can run safely.

Many of the compounds the researchers produced had never been synthesized in a continuous flow platform, says ­Timothy Jamison, the head of MIT’s Department of Chemistry and one of the project leaders. “That presents a lot of challenges even if there is a good precedent from the batch perspective,” he says.

By swapping in different components, the researchers can easily reconfigure the system to produce different drugs. “Within a few hours we could change from one compound to the other,” says chemical engineering professor Klavs Jensen, another of the project leaders.

This type of system could be especially useful in regions with few pharmaceutical storage facilities, because drugs can be produced on demand, eliminating the need for long-term storage.

“The dosages don’t have to have long-term stability,” Myerson says. “People line up, you make it, and they take it.”

Keep Reading

Most Popular

Europe's AI Act concept
Europe's AI Act concept

A quick guide to the most important AI law you’ve never heard of

The European Union is planning new legislation aimed at curbing the worst harms associated with artificial intelligence.

Uber Autonomous Vehicles parked in a lot
Uber Autonomous Vehicles parked in a lot

It will soon be easy for self-driving cars to hide in plain sight. We shouldn’t let them.

If they ever hit our roads for real, other drivers need to know exactly what they are.

supermassive black hole at center of Milky Way
supermassive black hole at center of Milky Way

This is the first image of the black hole at the center of our galaxy

The stunning image was made possible by linking eight existing radio observatories across the globe.

transplant surgery
transplant surgery

The gene-edited pig heart given to a dying patient was infected with a pig virus

The first transplant of a genetically-modified pig heart into a human may have ended prematurely because of a well-known—and avoidable—risk.

Stay connected

Illustration by Rose WongIllustration by Rose Wong

Get the latest updates from
MIT Technology Review

Discover special offers, top stories, upcoming events, and more.

Thank you for submitting your email!

Explore more newsletters

It looks like something went wrong.

We’re having trouble saving your preferences. Try refreshing this page and updating them one more time. If you continue to get this message, reach out to us at customer-service@technologyreview.com with a list of newsletters you’d like to receive.