Skip to Content

An On-Off Switch for Anxiety

In this video, a mouse with a fiberoptic cable implanted into his brain explores a four-arm maze. The animal has been genetically engineered to express light-sensitive proteins in a specific part of the amygdala, a brain region linked to fear. Mice are naturally afraid of open spaces, and at the beginning of the video, the mouse spends most of his time in one corner of the maze, occasionally dashing out to explore his environment. Turning on the light (as indicated by blue text) activates a specific neural circuit, which appears to make the mouse much braver, continually exploring all the parts of the maze. The video is shown at ten times normal speed.
March 10, 2011

In this video, a mouse with a fiberoptic cable implanted into his brain explores a four-arm maze. The animal has been genetically engineered to express light-sensitive proteins in a specific part of the amygdala, a brain region linked to fear. Mice are naturally afraid of open spaces, and at the beginning of the video, the mouse spends most of his time in one corner of the maze, occasionally dashing out to explore his environment. Turning on the light (as indicated by blue text) activates a specific neural circuit, which appears to make the mouse much braver, continually exploring all the parts of the maze. The video is shown at ten times normal speed.

Keep Reading

Most Popular

Large language models can do jaw-dropping things. But nobody knows exactly why.

And that's a problem. Figuring it out is one of the biggest scientific puzzles of our time and a crucial step towards controlling more powerful future models.

How scientists traced a mysterious covid case back to six toilets

When wastewater surveillance turns into a hunt for a single infected individual, the ethics get tricky.

The problem with plug-in hybrids? Their drivers.

Plug-in hybrids are often sold as a transition to EVs, but new data from Europe shows we’re still underestimating the emissions they produce.

It’s time to retire the term “user”

The proliferation of AI means we need a new word.

Stay connected

Illustration by Rose Wong

Get the latest updates from
MIT Technology Review

Discover special offers, top stories, upcoming events, and more.

Thank you for submitting your email!

Explore more newsletters

It looks like something went wrong.

We’re having trouble saving your preferences. Try refreshing this page and updating them one more time. If you continue to get this message, reach out to us at customer-service@technologyreview.com with a list of newsletters you’d like to receive.