Mimicking the pancreas

Researchers at MIT and in the UK have developed a better way to model pancreatic cancer, one of the most difficult types of cancer to treat.

Using a specialized gel that allows cells to mimic the extracellular matrix surrounding the pancreas, the team was able to grow tiny replicas of the organ with cells obtained from human patients. These “organoids” could allow researchers to study interactions between pancreatic tumors and their environment.

Traditionally, it has been difficult to grow pancreatic tissue in a manner that replicates both cancerous cells and their environment, because once the cells are removed from the body, they lose their cancerous traits. But the new gel supports the growth of both types of tissue.