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New x-ray system could image soft tissues.

X-rays are a crucial tool of medicine, but to image the body’s soft tissues they generally require contrast-enhancing agents that must be swallowed or injected, and their resolution is limited. But researchers at MIT and Massachusetts General Hospital have come up with a new approach that could dramatically change that, providing the most detailed images ever—including clear views of soft tissue without contrast agents.

x-ray of a human wrist
A sample x-ray of a human wrist demonstrates a new system’s ability to reveal very fine details.

The new technology could be smaller and cheaper than conventional systems, says Luis Velásquez-García, a principal research scientist at MIT’s Microsystems Technology Laboratories. It could also deliver higher resolution and reduce patients’ radiation exposure. The key is to produce coherent beams of x-rays from an array of micrometer-size point sources instead of a spread of beams from a single large point, as in conventional systems.

Velásquez-García says the technology would provide a unique view of the body’s organ systems. A simulation of the new system that the team performed with an eye from a cadaver clearly showed “all the structures, the lens, and the cornea,” he says.

Adapting hardware developed for microchip manufacturing, the researchers produced a nanostructured surface with an array of tiny tips, each of which can emit a beam of electrons. These, in turn, pass through a microstructured plate that emits a beam of x-rays. The resulting coherent beam is equivalent to something that can now be produced only by “incredibly expensive” systems at linear particle accelerators, Velásquez-García says. Those facilities were the first to demonstrate the diagnostic power of coherent beams—for example, revealing a cancerous tumor by showing the blood vessels supplying it.

“You can’t have a linear accelerator in every hospital,” he says. But the new system could potentially improve the resolution of conventional x-ray imagery by a factor of 100 with hardware that costs orders of magnitude less, he says.

The technology could also be applied beyond medicine. For example, it could be useful in airport baggage screening, differentiating a bottle of shampoo from a container of explosives.

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