Susan Young Rojahn

A View from Susan Young Rojahn

Pfizer "Disappointed" with First Results for Alzheimer's Drug Candidate

Amyloid-recognizing drug has no effect in patients with a high-risk genetic background.

  • July 24, 2012

On Monday, Pfizer announced the first of four expected sets of results for its Alzheimer’s drug bapineuzumab. As Steven Romano, head of the company’s Medicines Development Group said in a release, Pfizer is “disappointed”: the drug had no effect on the cognition or day-to-day functioning of patients with the largest known genetic risk for the late-stage onset form of the disease (ApoE4 carriers).

Bapineuzumab is an antibody—a protein that selectively grabs onto a specific protein—that recognizes beta-amyloid, the protein that forms tell-tale plaques in Alzheimer’s patient’s brains (see “Brain Scan for Alzheimer’s”). Because they riddle the brains of patients with the disease, amyloid plaques are one of the major suspects in the enigmatic disease. However, whether these plaques are an instigator of Alzheimer’s or a byproduct of the disease is still a major question for the field.

The company will continue with its trials in patients who do not carry the ApoE4 genetic variant. Results are expected later this summer.

Get stories like this before anyone else with First Look.

Subscribe today
Already a Premium subscriber? Log in.

Uh oh–you've read all of your free articles for this month.

Insider Premium
$179.95/yr US PRICE

More from Rewriting Life

Reprogramming our bodies to make us healthier.

Want more award-winning journalism? Subscribe to Insider Premium.
  • Insider Premium {! insider.prices.premium !}*

    {! insider.display.menuOptionsLabel !}

    Our award winning magazine, unlimited access to our story archive, special discounts to MIT Technology Review Events, and exclusive content.

    See details+

    What's Included

    Bimonthly magazine delivery and unlimited 24/7 access to MIT Technology Review’s website

    The Download: our daily newsletter of what's important in technology and innovation

    Access to the magazine PDF archive—thousands of articles going back to 1899 at your fingertips

    Special discounts to select partner offerings

    Discount to MIT Technology Review events

    Ad-free web experience

    First Look: exclusive early access to important stories, before they’re available to anyone else

    Insider Conversations: listen in on in-depth calls between our editors and today’s thought leaders

/
You've read all of your free articles this month. This is your last free article this month. You've read of free articles this month. or  for unlimited online access.