Hello,

We noticed you're browsing in private or incognito mode.

To continue reading this article, please exit incognito mode or log in.

Not a subscriber? Subscribe now for unlimited access to online articles.

Emily Singer

A View from Emily Singer

Genetic Mutations of the Year

A website highlights common genetic variations that made a splash in 2009.

  • January 5, 2010

SNPedia, a wiki-based database of single nucleotide polymorphisms (SNPs), has created my favorite top 10 list yet–the best SNPs of 2009, ranked according to “an elusive and ultimately subjective combination of medical importance, statistical believability, and overall general interest.”

SNPs are common genetic variations that have been highly scrutinized in recent years for their link to disease. SPNedia has compiled information on each of these SNPs, allowing people to analyze their own genetic profile by running their SNP data through it. (Tech Review contributors David Ewing Duncan and Misha Angrist have both tried it out.)

Topping the list is rs4244285, a variation in the drug metabolizing gene, CYP2C19, which determines how well you can metabolize the antiplatelet drug Plavix and other drugs. I wrote about this SNP last month and new devices being developed to easily identify it in hospitals and doctor’s offices.

The list includes a number of other variations that affect metabolism of a number of drugs, such as warfarin, or the susceptibility to side effects from certain drugs, such as muscle pain or weakness associated with statins and liver toxicity linked to the antibiotic floxacillin.

Check out the full list here.

Blockchain is changing how the world does business, whether you’re ready or not. Learn from the experts at Business of Blockchain 2019.

Register now
More from Rewriting Life

Reprogramming our bodies to make us healthier.

Want more award-winning journalism? Subscribe to MIT Technology Review.
  • Print + All Access Digital {! insider.prices.print_digital !}* Best Value

    {! insider.display.menuOptionsLabel !}

    The best of MIT Technology Review in print and online, plus unlimited access to our online archive, an ad-free web experience, discounts to MIT Technology Review events, and The Download delivered to your email in-box each weekday.

    See details+

    12-month subscription

    Unlimited access to all our daily online news and feature stories

    6 bi-monthly issues of print + digital magazine

    10% discount to MIT Technology Review events

    Access to entire PDF magazine archive dating back to 1899

    Ad-free website experience

    The Download: newsletter delivery each weekday to your inbox

    The MIT Technology Review App

  • All Access Digital {! insider.prices.digital !}*

    {! insider.display.menuOptionsLabel !}

    The digital magazine, plus unlimited site access, our online archive, and The Download delivered to your email in-box each weekday.

    See details+

    12-month subscription

    Unlimited access to all our daily online news and feature stories

    Digital magazine (6 bi-monthly issues)

    Access to entire PDF magazine archive dating back to 1899

    The Download: newsletter delivery each weekday to your inbox

  • Print Subscription {! insider.prices.print_only !}*

    {! insider.display.menuOptionsLabel !}

    Six print issues per year plus The Download delivered to your email in-box each weekday.

    See details+

    12-month subscription

    Print magazine (6 bi-monthly issues)

    The Download: newsletter delivery each weekday to your inbox

/3
You've read of three free articles this month. for unlimited online access. You've read of three free articles this month. for unlimited online access. This is your last free article this month. for unlimited online access. You've read all your free articles this month. for unlimited online access. You've read of three free articles this month. for more, or for unlimited online access. for two more free articles, or for unlimited online access.