We noticed you're browsing in private or incognito mode.

To continue reading this article, please exit incognito mode or log in.

Not an Insider? Subscribe now for unlimited access to online articles.

Rewriting Life

Systems Biology

The map of the genome is just the rule book; “systems biology” is the ball game.

Over the last few years, there’s been an explosion of information in biology. The mapping of the human genome gave biologists unprecedented detail about some 30,000 to 40,000 genes. Efforts are also under way to identify the thousands-and potentially millions-of proteins encoded by those genes. Researchers are now pursuing the next logical step in integrating all this data: systems biology.

The goal is to understand not just the functions of individual genes, proteins and smaller molecules like hormones, but to learn how all of these molecules interact within, say, a cell. Biologists hope to then use this information to generate more accurate computer models that will help unravel the complexities of human physiology and the underlying mechanisms of disease. The biggest payoff: faster development of more-effective drugs. “This is really opening up a whole new world, a new way of doing things,” says Aram Adourian, director of advanced technologies at Beyond Genomics, a systems biology startup in Waltham, MA.

A handful of academic groups, biotech firms and drug companies are embracing this new approach (see table). Pharmaceutical maker Eli Lilly is scheduled to open its new Center for Systems Biology in Singapore this spring. The center plans to spend $140 million over the next five years to develop more effective drugs using a systems approach. In Seattle, biotech pioneer Leroy Hood has recently founded the Institute for Systems Biology (see “Under Biology’s Hood,” TR September 2001) with the objective of better understanding complex systems like the immune system, as well as diseases like cancer. Beyond Genomics is using systems biology to identify better molecular targets for heart disease drugs and is collaborating with the Dublin, Ireland-based drug company Elan to develop new Alzheimer’s therapies.

This story is part of our March 2002 Issue
See the rest of the issue

Traditionally, drug researchers might identify a gene that is turned on or off in diseased patients and then develop a drug that regulates that gene or the protein it codes for. But many diseases involve a number of different genes and proteins, all interacting with each other in unique ways. Systems biology, by examining these complex interactions, could shed more light on how diseases alter cellular processes. This could help researchers hone in more efficiently on the crucial genes or proteins that cause illness, and which are therefore prime targets for new therapies. Researchers could also adjust their models to more accurately simulate the effects of a potential drug before testing it in humans, saving companies millions of dollars.

Systems biology has only recently become feasible with the development of an array of new lab tools-ranging from sophisticated protein identification methods to data-mining software-that allows researchers to process massive amounts of data. Beyond Genomics, for example, collects samples such as blood, tissue or brain fluid and then uses a number of newly developed analytical tools to identify the main genes, proteins and smaller molecules that behave differently in healthy versus diseased patients. And rather than identifying every type of molecule in a sample-“That would be a daunting task,” says Adourian-the company zeroes in on only those that appear to be involved in disease.

The new data are then combined with information from public databases and fed into a computer that maps out the possible interactions between the molecules. This allows the company to spot molecules that are likely to make good targets for new drugs in a matter of weeks, as opposed to the years traditional methods might take.

Even a single cell is an extremely complex system filled with thousands of molecules that researchers have yet to identify. And it could be more than a decade before systems biology is able to construct an accurate model of all these interacting elements in a cell. Yet as the approach evolves, and as databases on genes, proteins and other factors continue to grow, researchers will move closer to that goal-and even a partial understanding could greatly aid the drug discovery process. “I think there are quite exciting opportunities in biotechnology for companies that take on systems biology correctly,” says Hood, acknowledging the technical challenges inherent in this multifaceted research.

Eventually, researchers would like to look at systems even more complex than the cell. Some day systems biology might make it possible to model an organ, like a heart, and ultimately a whole organism. Then the term “holistic healing” would take on a whole new meaning.

The Big Picture
Companies exploiting systems biology

Institute/Company Location Focus Institute for Systems Biology Seattle, WA Understand human physiology and disease Beyond Genomics Waltham, MA Identify new drug targets Lilly Center for Systems Biology Singapore Develop new drugs SurroMed Mountain View, CA Mine multiple biological data for new drug targets Alliance for Cellular Signaling Dallas, TX Map all interactions between proteins in a cell

Want to go ad free? No ad blockers needed.

Become an Insider
Already an Insider? Log in.
More from Rewriting Life

Reprogramming our bodies to make us healthier.

Want more award-winning journalism? Subscribe to Insider Plus.
  • Insider Plus {! insider.prices.plus !}*

    {! insider.display.menuOptionsLabel !}

    Everything included in Insider Basic, plus the digital magazine, extensive archive, ad-free web experience, and discounts to partner offerings and MIT Technology Review events.

    See details+

    Print + Digital Magazine (6 bi-monthly issues)

    Unlimited online access including all articles, multimedia, and more

    The Download newsletter with top tech stories delivered daily to your inbox

    Technology Review PDF magazine archive, including articles, images, and covers dating back to 1899

    10% Discount to MIT Technology Review events and MIT Press

    Ad-free website experience

You've read of three free articles this month. for unlimited online access. You've read of three free articles this month. for unlimited online access. This is your last free article this month. for unlimited online access. You've read all your free articles this month. for unlimited online access. You've read of three free articles this month. for more, or for unlimited online access. for two more free articles, or for unlimited online access.