50 Smartest Companies 2015
- 1
Why
Extending its battery technology from cars to residential and commercial applications.Company Details$5 billion
Projected investment required to build its battery “gigafactory” in Nevada - 2
Why
Fast-growing smartphone vendor is maturing beyond its original “cut-price Apple” model with ideas like flash sales over its mobile messaging platform.Company Details$45 billion
Most recent valuation for the private company - 3
Why
Shifting its fast DNA-reading machines from research applications primarily to hospitals and cancer clinics.Company Details90 percent
Proportion of all DNA data estimated to be produced on its machines - 4
- 5
Why
Its cheap DNA tests help would-be parents plan ahead. Now it sells cancer screens.Company Details3.6 percent
Proportion of U.S. couples that use its tests before trying to conceive - 6
Why
Aggressively expanding its renewable energy products and building a business to provide electricity to the developing world.Company Details1.1 billion
number of people worldwide who don’t have access to electricity - 7
Why
China’s most-used Internet service portal is expanding by investing in companies inside and outside its home market.Company Details549 million
Active monthly users on WeChat and its related Weixin service - 8
Why
Testing cancer treatments that use a person’s own immune cells.Company Details$304 million
Amount it raised in the largest biotech IPO of 2014 - 9
Why
The factory it is planning to build in Buffalo will be the Western Hemisphere’s largest manufacturer of silicon solar panels, the company says.Company Details177,000
Number of U.S. customers who lease SolarCity’s rooftop solar panels - 10
Why
It’s producing innovative original content and inking distribution deals with cable companies.Company Details31
Number of Emmy nominations for its original programming in 2014 - 11
Why
The first baby conceived with the help of its stem-cell treatment has been born.Company Details$25,000
Maximum amount it charges IVF clinics for the treatment - 12
- 13
Why
Robots now used in its fulfillment centers could make the facilities far more efficient.Company Details$89 billion
2014 sales - 14
Why
Maker of a heart monitor that connects to an iPhone and automatically detects irregular heartbeats.Company Details2 million
Number of ECG readings on its devices so far - 15
Why
Began selling the first pill that can cure most cases of hepatitis C.Company Details$3.6 billion
Sales of the drug in the first three months of 2015 - 16
Why
Its new smart watch and its Apple Pay digital wallet set the pace for competitors.Company Details1 million
Number of Apple Watches ordered the day they went on sale, according to outside estimates - 17
Why
Having created what it calls the world’s first 3-D electronics printer, the startup is commercializing promising new materials like conductive ink.Company Details5,000
Factor by which its inks improve conductivity, according to the company - 18
Why
Offering more affordable water desalination at a scale never before achieved.Company Details300,000
Number of people to be served by the plant it is building with partners in Carlsbad, California - 19
Why
Its Icelandic gene database is yielding clues that help it decide which drugs to develop.Company Details10,000
Number of sequenced genomes in the database - 20
Why
Has gained customers for its novel batteries, which can store surplus wind and solar energy.Company Details$129 million
Money raised from Aquion’s investors - 21
Why
The Chinese Internet company’s new deep-learning research lab has produced notable results in facial and speech recognition.Company Details70 percent
Increase in 2014 research spending, to $1.125 billion - 22
Why
The rocket company has made progress on the technical challenge of landing and reusing unmanned rockets.Company Details9
Number of missions completed in the last year - 23
Why
Uses new materials and manufacturing techniques to make solid-state batteries that store twice as much energy as rival lithium-ion technologies.Company Details$15 million
Size of recent investment by appliance maker Dyson (General Motors is also a backer) - 24
Why
Pioneering technology to be used in advanced computer vision systems for cars.Company Details$12 billion
Freescale’s value in a proposed acquisition by a Dutch semiconductor maker - 25
Why
Its user-friendly, relatively cheap robots have found a strong market. In May, Teradyne agreed to buy the company for $285 million.Company Details70 percent
Increase in revenue from 2013 to 2014 - 26
Why
Took a lead in cancer immunotherapy with Opdivo, a life-saving drug for skin and lung cancer.Company Details$12,500
monthly cost of the drug - 27
Why
Though some doctors’ organizations oppose the idea of remote medicine and are trying to limit the practice, this fast-growing telemedicine company is nearing an IPO.Company Details10 million
Number of U.S. members in its remote-consultation service - 28
Why
Its chips are crucial for cutting-edge technologies like deep learning and driverless cars.Company Details7,000
Number of patents it holds - 29
Why
Big ad revenue is being invested in improvements to apps like Messenger and in its new agreement to directly host work by leading news organizations.Company Details1.44 billion
Number of monthly active users worldwide in the first quarter of 2015 - 30
Why
It is turning around the prospects for RNA interference, a promising type of gene therapy that has been challenging to use.Company Details6
Number of the company’s drugs in human testing - 31
Why
Although sales have been soft for its easy-to-train Baxter robot, the company’s newest model, Sawyer, is impressively precise and fast.Company Details$114 million
Funding raised - 32
Why
The giant of LED lighting has made the efficient technology even more affordable.Company Details$5
Retail price of two bulbs that will last for a decade - 33
Why
Its Calyxt division uses quick gene editing to create crops that might not need regulation as GMOs.Company Details1 year
Time it took to create a genetically engineered potato that should be healthier to eat when fried - 34
Why
Its gene therapies may cure, not just treat, diseases like sickle-cell anemia.Company Details9
Number of patients treated so far in studies - 35
Why
Reinvented the elevator with magnetic levitation technology, resulting in a system that can transport more people and move horizontally.Company Details6.4 billion euros
Company’s global elevator sales in 2014 - 36
Why
Its workplace communications app is taking off.Company Details300 million
Number of messages sent via Slack each month - 37
Why
The Japanese company runs a hugely popular messaging and free calling app that actually generates revenue.Company Details205 million
Number of monthly active users - 38
Why
Using computer science to simulate richer virtual worlds, with applications in gaming and virtual reality.Company Details$20 million
Improbable’s funding from Andreessen Horowitz this year - 39
Why
Its deep-learning technology automatically spots tumors in medical scans.Company Details$1.7 billion
Total estimated value of the market for medical image analysis software - 40
Why
Helps companies including PayPal, Dell, and Expedia take Bitcoin payments without having to hold onto the cryptocurrency.Company Details2.9 million
Number of Bitcoin accounts registered with Coinbase - 41
Why
Its popular travel planning apps in Europe combine information on taxis, car rental, bike sharing, and public transportation systems.Company Details40 million
Number of journeys planned on its system every day - 42
Why
Moving to dominate the commercialization of 3-D printing by developing a super-fast assembly line.Company Details50
Factor by which 3D Systems hopes to increase the speed of 3-D printing - 43
Why
This Italian-based insurer will use fitness data from wearables, as well as other health data, to calculate insurance rates for customers who choose to participate.Company Details60
Number of countries in which the company operates - 44
Why
Developing synthetic biology in multiple fields for health, energy, consumer, and environmental applications.Company Details$41 million
Amount paid to acquire the maker of a patented transgenic apple - 45
Why
Helping researchers and drug companies move genetic data into Amazon’s cloud.Company Details56,000
Number of computer processors the company uses to analyze DNA - 46
Why
Novel research into artificial intelligence could help the company in its long-term plan to make big data more useful.Company Details14
Number of hospitals in North America that have signed up to use the Watson AI system to guide cancer therapy - 47
Why
Innovative new formats include “Snapchat Stories,” which put videos and photos together to tell a story, and a platform for media organizations that is used by ESPN, CNN, and others.Company Details1 billion
Number of Snapchat Stories viewed per day - 48
Why
Its HoloLens augmented-reality technology reflects the new CEO’s turnaround ambitions.Company Details$15 billion:
projected annual revenue for its commercial cloud business - 49
Why
Developing ultrathin, flexible, rechargeable batteries that can be printed cheaply on commonly used industrial screen printers.Company Details - 50
Why
It’s testing ideas like ride-share services and driver deliveries.Company Details162,037
Number of active Uber drivers as of December 2014