Organs on demand: 10 Breakthrough Technologies 2023

Engineered organs could put an end to transplant waiting lists.

Antonio Regaladoarchive page

January 9, 2023

Joe Carotta for NYU Langone Health

WHO

eGenesis, Makana Therapeutics, United Therapeutics

WHEN

10 to 15 years

For two months last year, a 57-year-old man named David Bennett lived with a pig heart beating inside his chest. Surgeons at the University of Maryland had put it there to see: Could a gene-edited pig’s heart keep a person alive?

Far more people need an organ transplant to live than can get one. There are around 130,000 organ transplants each year around the world, but many more people die waiting for an organ or because they never even made it onto a transplant waiting list.

Animal organs are one potential solution. But it’s not easy to overcome the human body’s natural revolt against them. For example, sugars on the surface of pig tissue can send our immune system into attack mode. Drugs can help mute the response, but it’s not enough. So biotech companies have used gene editing to modify pigs, removing those sugar molecules and adding other genes to make the pigs seem more human-like.

By editing the DNA of pigs in this way, several biotech companies have now created animals whose organs are more compatible with human bodies. Though Bennett died, and a virus was found in the transplanted organ, his doctors claim the pig heart he received never developed classic signs of organ rejection. Now they’re planning studies with more patients.

In the future, organ engineering might not involve animals at all. Researchers are in the early stages of exploring how to engineer complex tissue from the ground up. Some are 3D-printing scaffolds in the shape of lungs. Others are cultivating blob-like “organoids” from stem cells to imitate specific organs. In the long term, researchers hope to grow custom organs in factories.

Whether they’re grown in animals or built inside manufacturing plants, an unlimited supply of organs could make transplantation more common, and give far more people access to replacement parts.

Read about Martine Rothblatt, the entrepreneur dreaming about factories of unlimited organs.