Skip to Content
Biotechnology and health

The woman whose brain staved off her family’s Alzheimer’s

November 4, 2019
MRI image of brain
MRI image of brainWikimedia

A rare genetic mutation may have saved one woman from getting Alzheimer’s, and now drug developers are interested, according to the New York Times.

The foolishness: The discovery was made studying an extended family in the mountains of Colombia who are afflicted with an early-onset form of Alzheimer’s disease. Because of a gene defect passing through the family, many get sick by their 40s and die at around 60. They call it “La Bobera,” or the foolishness, according to the Times.

The woman who was spared: Now researchers say they’ve found one woman who was mysteriously spared, and they think they know why. The woman, who lives in Medellín (and who remains anonymous), didn't experience a loss of mental faculties until she was past 70, even though her brain was full of the sticky amyloid plaques usually associated with the brain disease. 

Saving mutation: Researchers are reporting today in the journal Nature Medicine they have a good guess at what shielded her brain. The woman, they say, has a second rare mutation in a different gene, called APOE, which appears to have protected her. 

It’s an antidote? Yes: at a genetic level, the woman’s genome seems to have contained, simultaneously, both the cause of Alzheimer’s and the antidote to it. 

That’s a big deal because it could give drug makers new ideas for how to stop the disease in the rest of us. Scientists already know that what version of the APOE gene a person has influences the risk of dementia. Some are even considering gene therapy to give people healthier versions of APOE. Now, through a single person, researchers seem to have hit on what could be the optimal version.

Deep Dive

Biotechnology and health

Scientists are finding signals of long covid in blood. They could lead to new treatments.

Faults in a certain part of the immune system might be at the root of some long covid cases, new research suggests.

The first gene-editing treatment: 10 Breakthrough Technologies 2024

Sickle-cell disease is the first illness to be beaten by CRISPR, but the new treatment comes with an expected price tag of $2 to $3 million.

This baby with a head camera helped teach an AI how kids learn language

A neural network trained on the experiences of a single young child managed to learn one of the core components of language: how to match words to the objects they represent.

We’ve never understood how hunger works. That might be about to change.

Scientists have spent decades trying to unravel the intricate mysteries of the human appetite. Are they on the verge of finally determining how this basic drive functions?

Stay connected

Illustration by Rose Wong

Get the latest updates from
MIT Technology Review

Discover special offers, top stories, upcoming events, and more.

Thank you for submitting your email!

Explore more newsletters

It looks like something went wrong.

We’re having trouble saving your preferences. Try refreshing this page and updating them one more time. If you continue to get this message, reach out to us at customer-service@technologyreview.com with a list of newsletters you’d like to receive.