The U.S. government says it will move forward with wider tests of its Zika vaccine after the results from a safety study initiated last summer were promising.
The vaccine, called a DNA vaccine, uses genes from the virus to create an immune response. It was first given to volunteers last August as concern spread over a cluster of Zika cases in Miami.
The new phase of the vaccine tests began Wednesday at Baylor College of Medicine in Houston, one of 11 U.S. locations that will enroll up to 5,000 healthy adults, according to Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, which developed the vaccine.
In a call with reporters on Friday, Fauci said initial results in 40 volunteers indicate that the vaccine produced an immune response against Zika and didn’t cause serious side effects.
Companies are developing novel DNA vaccines to protect against a range of infections and to treat cancer.
GeneOne Life Science
Flu, hepatitis C
Ichor Medial Systems
HIV, malaria, breast cancer, melanoma
MERS, Ebola, Zika
The threat has waned since Zika spread across Latin America and reached the U.S. last summer, but Fauci cautioned that the virus could return. People who get the mosquito-borne virus generally have only mild symptoms, but infection during pregnancy has been linked to serious birth defects.
The vaccine being tested, as well as other DNA vaccines, contains genetic material from the virus which, once injected into muscle, trains the body to mount an immune response against the virus.
The appeal of DNA vaccines is that they can be designed quickly to counter emerging threats and are easier to manufacture than traditional vaccines. The NIH previously developed a DNA vaccine against West Nile virus, but it was never commercialized.
Companies developing DNA vaccines include Astella Pharma, Inovio Pharmaceuticals, and GeoVax, whose products aim to protect against malaria, peanut allergy, and some types of cancer. So far, however, no DNA vaccine has reached the market.
To prove that the Zika vaccine protects against infection, Fauci says, the trial will eventually be expanded to sites in Puerto Rico, Brazil, Peru, Costa Rica, Panama, and Mexico, where the virus is still being transmitted.
DeepMind’s cofounder: Generative AI is just a phase. What’s next is interactive AI.
“This is a profound moment in the history of technology,” says Mustafa Suleyman.
What to know about this autumn’s covid vaccines
New variants will pose a challenge, but early signs suggest the shots will still boost antibody responses.
Human-plus-AI solutions mitigate security threats
With the right human oversight, emerging technologies like artificial intelligence can help keep business and customer data secure
Next slide, please: A brief history of the corporate presentation
From million-dollar slide shows to Steve Jobs’s introduction of the iPhone, a bit of show business never hurt plain old business.
Get the latest updates from
MIT Technology Review
Discover special offers, top stories, upcoming events, and more.