Skip to Content

A Laboratory for Rare Cells Sheds Light on Cancer

A way of capturing cancer cells from the bloodstream opens a new front in personal cancer treatment.

In 1869, the Australian physician Thomas Ashworth put the blood of woman who had died of breast cancer under a microscope. Peering through it, he spotted “cells identical with those of the cancer itself.”

Tumor cells
Dangerous mix: Tumor cells collected from the bloodstream of a woman with breast cancer are seen growing in the lab.

He postulated that the large and abnormal cells in her blood might explain metastases all over her body, more than 30 of them. The cancer cells were probably moving through the circulatory system, creating the rash of tumors.

In a new report published in Science, researchers at Massachusetts General Hospital say that after capturing these “circulating tumor cells” from patients fighting cancer, they have been able to keep them growing in the lab, and tested drugs against them.

The work is a “critically important proof of concept study” that shows how researchers might one day undertake personalized studies on patients’ own tumor cells, says Stefanie Jeffrey, a cancer expert at Stanford University. 

The circulating tumor cells are extremely rare—they account for one of every billion cells found in a patient’s blood. Yet the researchers were able to pluck tumor cells from the blood of six patients with advanced breast cancer and then culture them, or keep them alive and multiplying. While scientists at Baylor University first showed last year that culturing tumor cells from the blood was possible, the Boston scientists also managed to place the cells into micro-vessels—each holding about 200 cells—and test whether they could be killed with one or more drug treatments.

Daniel Haber, the Mass. General oncologist who led the study, says the approach could eventually help resolve common situations he faces in his clinic, when patients stop responding to an initial treatment. Which drug to give them next is often little better than a guess. “You need to know what you are treating,” says Haber.

Over the last decade, a huge amount of effort has gone into engineering devices able to capture cancer cells in the blood, including technologies like “nano Velcro,” magnetic sifters, and simple paper filters. The Mass. General device, called the CTC-iChip, was created over the last three years in the lab of engineer Mehmet Toner and is considered one of the most advanced (see “Device Finds Stray Cancer Cells in Patients’ Blood”).

At Toner’s lab, vials of blood set into the instrument rock back and forth, dripping fluid through a series of microchannels that remove normal blood cells. After about half an hour, all that’s left is a plastic bag filled with a small number of the rare cancer cells. Development of the device has been paid for by Johnson & Johnson, which has spent $30 million funding the work.

Johnson and Johnson already sells a system called Cellsearch that can count tumor cells in the blood. But that device, approved by the FDA in 2004, has not proved so useful to doctors. The number of tumor cells in someone’s blood predicts their chance of surviving, but it doesn’t help doctors know how to treat the patient.

Some doctors aren’t sure that personalized testing of tumor cells will help either. One problem is that it’s very difficult, and took the Mass General team months of effort to grow cells from the patients. That’s too long to be helpful in picking a treatment; some patients don’t survive that long. “It’s expensive and it takes several months. I don’t think this is going to have a future for patient care,” says Massimo Cristofanilli, an oncology specialist at Jefferson University Hospital, in Philadelphia.

Stanford’s Jeffrey adds that it’s still unclear whether cancer cells in the blood are really the same as those in a person’s tumors. That means it’s uncertain if tumors and the cells will respond in the same way to drug treatments. 

Instead, the technology may prove more important in studying how metastases occur. As Ashworth hypothesized in the 19th century, cancer cells must spread through the bloodstream. Yet very little is known about what makes a cell metastatic and able to escape into the blood and take hold elsewhere.

“These are very rare cells that circulate for a very short time and disappear,” says Haber. Yet they “may be responsible for the vast majority of cancer deaths. This is a technology that lets you look at something you could never see before.” 

Keep Reading

Most Popular

A Roomba recorded a woman on the toilet. How did screenshots end up on Facebook?

Robot vacuum companies say your images are safe, but a sprawling global supply chain for data from our devices creates risk.

A startup says it’s begun releasing particles into the atmosphere, in an effort to tweak the climate

Make Sunsets is already attempting to earn revenue for geoengineering, a move likely to provoke widespread criticism.

10 Breakthrough Technologies 2023

Every year, we pick the 10 technologies that matter the most right now. We look for advances that will have a big impact on our lives and break down why they matter.

These exclusive satellite images show that Saudi Arabia’s sci-fi megacity is well underway

Weirdly, any recent work on The Line doesn’t show up on Google Maps. But we got the images anyway.

Stay connected

Illustration by Rose Wong

Get the latest updates from
MIT Technology Review

Discover special offers, top stories, upcoming events, and more.

Thank you for submitting your email!

Explore more newsletters

It looks like something went wrong.

We’re having trouble saving your preferences. Try refreshing this page and updating them one more time. If you continue to get this message, reach out to us at customer-service@technologyreview.com with a list of newsletters you’d like to receive.