Skip to Content

Bases to Bytes

Cheap sequencing technology is flooding the world with genomic data. Can we handle the deluge?
April 25, 2012

The cost of sequencing human genomes is plunging—in the most advanced genomics centers, it’s falling five times faster than the cost of computing. Increasingly, people are getting their DNA sequenced by companies and research labs in a search for clues about genetic variation and disease.

But the industry must figure out how to cheaply store all the resulting data. Each of the 3.2 billion DNA base pairs in a human genome can be encoded by two bits—800 megabytes for the entire genome. But considerable data about each base is usually collected, and genes are often sequenced many times to ensure accuracy, so it’s common to save around 100 gigabytes when sequencing a human genome with a machine made by industry leader Illumina. Keeping this much data about every person on the planet would require about as much digital storage as was available in the whole world in 2010.

The trick, then, will be to save less. Harvard geneticist George Church says that eventually only the differences between a newly sequenced genome and a reference genome will need to be stored. That information could be encoded in as little as four megabytes. Then your genome might be just another e-mail attachment.

Information graphics by Infographics.com

Keep Reading

Most Popular

Geoffrey Hinton tells us why he’s now scared of the tech he helped build

“I have suddenly switched my views on whether these things are going to be more intelligent than us.”

ChatGPT is going to change education, not destroy it

The narrative around cheating students doesn’t tell the whole story. Meet the teachers who think generative AI could actually make learning better.

Meet the people who use Notion to plan their whole lives

The workplace tool’s appeal extends far beyond organizing work projects. Many users find it’s just as useful for managing their free time.

Learning to code isn’t enough

Historically, learn-to-code efforts have provided opportunities for the few, but new efforts are aiming to be inclusive.

Stay connected

Illustration by Rose Wong

Get the latest updates from
MIT Technology Review

Discover special offers, top stories, upcoming events, and more.

Thank you for submitting your email!

Explore more newsletters

It looks like something went wrong.

We’re having trouble saving your preferences. Try refreshing this page and updating them one more time. If you continue to get this message, reach out to us at customer-service@technologyreview.com with a list of newsletters you’d like to receive.