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Research to Watch

February 23, 2010

Project: Applied Statistical Genetics Group
Wellcome Trust Sanger Institute
www.sanger.ac.uk/research/projects/appliedstatisticalgenetics

Finding ways to analyze large amounts of genetic data and extract information related to diseases that involve multiple genes.

Project: Cancer Biology and Genetics Program
Sloan-Kettering Institute
www.mskcc.org

Testing a microfluidic chip that will measure differences in how genes are expressed in tumors.

Project: Coriell Personalized Medicine Collaborative
Coriell Institute for Medical Research
cpmc.coriell.org

Enrolling 100,000 participants in a research study to measure how genetic information can improve health.

Project: Diagnostic Investigation of Sudden Cardiac Event Risk
CardioDX
www.cardiodx.com/clinical-studies/cardiac-arrhythmia

Developing a genetic test that will identify patients at risk of sudden cardiac death who should receive an implantable defibrillator.

Project: EuroGenTest
Catholic University of Leuven and others
www.eurogentest.org

An EU-funded consortium seeking to standardize genetic testing and establish guidelines for doctors and patients.

Project: Global Alliance for Pharmacogenomics
National Institutes of Health, RIKEN Yokohama Institute
www.nigms.nih.gov/Initiatives/PGRN/GAP

An American-Japanese scientific alliance studying pharmacogenomics across a broad array of medical conditions, including depression, AIDS, and asthma.

Project: Pharmacogenomics Knowledge Base
Stanford University Medical Center and others
www.pharmgkb.org

An international consortium building a database detailing the influence of genetic variations on drug reactions.

Project: Plavix, Effient Comparative Effectiveness Study
Medco
www.medcoresearch.com/community/pharmacogenomics

Investigating whether using genetic tests to determine a patient’s sensitivity to certain drugs is more cost-effective than choosing drugs that are less affected by genetic variations.

Project: The 1000 Genomes Project
Wellcome Trust Sanger Institute, Beijing Genomics Institute Shenzen, National Human Genome Research Institute
www.1000genomes.org

Sequencing the genomes of about 1,200 people around the world to create a database of biomedically relevant genetic variation.

Project: The Cancer Genome Atlas
National Cancer Institute, National Human Genome Research Institute
cancergenome.nih.gov

Sequencing thousands of samples from over 20 types of tumors to understand the genetic changes that underlie these cancers.

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