Skip to Content

Ancient Human Genome Sequenced

Researchers say their subject had brown eyes, thick hair, and dry ear wax.
February 10, 2010

Thanks to new sequencing technologies, and a few tufts of hair rescued from a museum basement, researchers have reconstructed the genome sequence of a man who lived in western Greenland about 4000 years ago. Researchers from the University of Copenhagen were able to read about 80 percent of his genome at a level of accuracy comparable to the genome sequences of living people. (Only eight human genome sequences have been published to date.)

An artist’s impression of “Inuk,” an ancient Eskimo whose
genome has been sequenced. Credit: Nuka Godfredsen

That level of accuracy allowed scientists to analyze 350,000 single nucleotide polymorphisms, or SNPs–spots of common genetic variation within the genome–enabling them to draw conclusions about both the physiology of the man and his origins.

According to a commentary accompanying the paper in Nature,

“he had an A+ blood group, brown eyes, non-white skin, thick dark hair and ‘shovel-graded’ front teeth typical of Asian and Native American populations. What’s more, he had an increased susceptibility to baldness, dry earwax and a metabolism and body-mass index commonly found in those who live in cold climates.”

By comparing the SNP data with that of several surrounding populations, researchers were able to pinpoint his geographical origin.

Surprisingly, the ancient eskimo proved to be most closely related to three Old World Arctic populations: the Nganasans, Koryaks and Chukchis of the Siberian far east. This suggests that there was a substantial and relatively recent migration across the Bering Strait and over North America to Greenland. The authors’ analysis indicates that the Saqqaqs diverged from the Chukchis about 200 generations (5,400 years) ago, implying that the ancestral Saqqaqs separated from their Old World relatives almost immediately before their migration to the New World.

Scientists had previously analyzed DNA from Neandertal bone and tooth samples, but not to this level of accuracy. Sequencing ancient DNA samples is notoriously difficult, thanks to degraded DNA and contamination from bacteria, fungus and humans handling the samples. In this case, researchers say only Europeans handled the DNA, and the sample itself was found to have no European ancestry. They used sequencing technology from the company Illumina.

According to the New York Times, the hair, originally dug out of the permafrost at Qeqertasussuk on the west coast of Greenland in 1986, was kept in a plastic bag in the National Museum of Denmark. It was found with other waste, and the scientists speculate that it was the result of a haircut.

“There it moldered, unfrozen, until discovered by Dr. Willerslev, an expert on ancient DNA. Having spent two months digging for ancient human DNA in Greenland without finding any human remains, he concluded that ancient Greenlanders must have disposed of their dead by laying them on the sea ice. Only on complaining of his bad luck to a friend did he learn that the friend’s father had found the hair sample 20 years earlier.”

Keep Reading

Most Popular

light and shadow on floor
light and shadow on floor

How Facebook and Google fund global misinformation

The tech giants are paying millions of dollars to the operators of clickbait pages, bankrolling the deterioration of information ecosystems around the world.

protein structures
protein structures

DeepMind says it will release the structure of every protein known to science

The company has already used its protein-folding AI, AlphaFold, to generate structures for the human proteome, as well as yeast, fruit flies, mice, and more.

ASML machine
ASML machine

Inside the machine that saved Moore’s Law

The Dutch firm ASML spent $9 billion and 17 years developing a way to keep making denser computer chips.

brain map
brain map

This is what happens when you see the face of someone you love

The moment we recognize someone, a lot happens all at once. We aren’t aware of any of it.

Stay connected

Illustration by Rose WongIllustration by Rose Wong

Get the latest updates from
MIT Technology Review

Discover special offers, top stories, upcoming events, and more.

Thank you for submitting your email!

Explore more newsletters

It looks like something went wrong.

We’re having trouble saving your preferences. Try refreshing this page and updating them one more time. If you continue to get this message, reach out to us at customer-service@technologyreview.com with a list of newsletters you’d like to receive.