Skip to Content

New Insight into the Genetics of Schizophrenia

The findings highlight the role that rare duplications and deletions play in disease.
March 28, 2008

New research suggests that a number of rare DNA deletions and duplications contribute to schizophrenia, potentially providing a new model for the genetic basis of the disease. The findings also highlight the importance of new technologies that allow scientists to efficiently scan the genome for small structural changes.

According to the New York Times,

Experts said the study, while not identifying the cause of the disorder, provided a striking demonstration of how new gene-scanning technology can open a new frontier in the quest to understand the biology of mental disorders.

While scientists have long known that schizophrenia has a genetic component, pinning down specific genes has been difficult. The new findings may explain why. Researchers compared genetic duplications and deletions in healthy people’s genomes with those of people with schizophrenia. They found that these changes were three times more likely to appear in the genomes of people with schizophrenia. But each individual mutation was rare, with some seen only in single individuals or families.

From the New York Times:

The new study suggests that, if anything, the genetics of the disorder are even more complex than many had presumed. But if replicated, experts said, the study’s results will significantly alter the course of psychiatric research.

“This paper represents a paradigm shift in the way we think about identifying genes in schizophrenia,” said Dr. Matthew State, director of the neurogenetics program at Yale University School of Medicine, who was not involved in the research. “That is what the authors say in the paper, and it’s true.”

The findings were published online in the journal Science.

Keep Reading

Most Popular

10 Breakthrough Technologies 2024

Every year, we look for promising technologies poised to have a real impact on the world. Here are the advances that we think matter most right now.

Scientists are finding signals of long covid in blood. They could lead to new treatments.

Faults in a certain part of the immune system might be at the root of some long covid cases, new research suggests.

AI for everything: 10 Breakthrough Technologies 2024

Generative AI tools like ChatGPT reached mass adoption in record time, and reset the course of an entire industry.

What’s next for AI in 2024

Our writers look at the four hot trends to watch out for this year

Stay connected

Illustration by Rose Wong

Get the latest updates from
MIT Technology Review

Discover special offers, top stories, upcoming events, and more.

Thank you for submitting your email!

Explore more newsletters

It looks like something went wrong.

We’re having trouble saving your preferences. Try refreshing this page and updating them one more time. If you continue to get this message, reach out to us at customer-service@technologyreview.com with a list of newsletters you’d like to receive.