Skip to Content

Biolubricant for Arthritic Joints

A protein found in the fluid that surrounds cartilage holds promise.

Researchers at Brown University have discovered that a protein found in the fluid surrounding cartilage acts as a shock absorber, a finding that could lead to better treatments for arthritis. The protein, called lubricin, is found in synovial fluid, a viscous substance inside joints. To learn more about its properties, Gregory Jay, associate professor of emergency medicine and the project’s leader, compared two samples of joint fluid: one normal and the other from a person with a rare disease in which the body does not make lubricin. The researchers implanted fluorescent beads in the fluids. Then they used a video camera to track the beads. The tracks enabled them to calculate the viscosity and other properties of the two fluids. They found that synovial fluid is more effective at protecting joints when lubricin binds to ­hyaluronate, a salt also found in the fluid. Hyaluronate injections are already used to treat arthritis; the researchers hope that augmenting them with lubricin will boost their protective power, shielding cartilage from damage. Jay’s team is preparing a therapy for animal testing.

Multiple fluorescent microspheres (left half of image) were placed in synovial fluid and tracked with a charge-coupled device camera. The random movements of the particles were plotted (right half of image) and used to determine the fluid’s biophysical properties.

Keep Reading

Most Popular

Large language models can do jaw-dropping things. But nobody knows exactly why.

And that's a problem. Figuring it out is one of the biggest scientific puzzles of our time and a crucial step towards controlling more powerful future models.

The problem with plug-in hybrids? Their drivers.

Plug-in hybrids are often sold as a transition to EVs, but new data from Europe shows we’re still underestimating the emissions they produce.

Google DeepMind’s new generative model makes Super Mario–like games from scratch

Genie learns how to control games by watching hours and hours of video. It could help train next-gen robots too.

How scientists traced a mysterious covid case back to six toilets

When wastewater surveillance turns into a hunt for a single infected individual, the ethics get tricky.

Stay connected

Illustration by Rose Wong

Get the latest updates from
MIT Technology Review

Discover special offers, top stories, upcoming events, and more.

Thank you for submitting your email!

Explore more newsletters

It looks like something went wrong.

We’re having trouble saving your preferences. Try refreshing this page and updating them one more time. If you continue to get this message, reach out to us at customer-service@technologyreview.com with a list of newsletters you’d like to receive.