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Eye on Cells

New cell imaging technology could give researchers an insight into complicated diseases
January 1, 2007

In physicist Michael Feld’s MIT lab, researchers watch red blood cells vibrating and undulating in real time, thanks to a technology known as quantitative phase imaging. The technology splits a light wave in two, passes one wave through a cell, and then recombines it with the other wave.

Quantitative phase imaging can depict red blood cells (shown above) with 0.2-nanometer resolution.

Analyzing the resulting interference pattern provides a remarkable view of living, moving cells not possible with electron microscopy, which requires careful sample preparation. Researchers in Feld’s lab are studying the dynamics of red blood cells’ membranes to gain insight into diseases such as malaria, leukemia, and sickle-cell anemia. Others are studying neuron dynamics. And while the MIT group has produced images with an astonishing 0.2-­nanometer resolution, Feld ultimately hopes to create 3-D images of the inner structures of living cells, too.

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