Humanizing the Pig
Recent studies have shown that pigs could donate hearts and kidneys for people. But livers, which rely on enzymes specific to each species, are more difficult. Now comes a promising new approach: partly humanize the pig’s liver. Researchers at Ximerex in Omaha, Neb., infused human liver cells into fetal pigs and watched the cells produce human liver enzymes. But with no room in the pigs’ livers, the human cells ended up in the spleen. To solve this space problem, Ximerex is developing genetically modified pigs programmed to kill off 20 to 80 percent of their own liver cells. The next step will be to transfer the pigs’ immune cells to the patient to build up a tolerance of the hybrid organ. Working with the University of Nebraska, Ximerex hopes to begin human trials in 2005, says President William Beschorner.
Keep Reading
Most Popular

These materials were meant to revolutionize the solar industry. Why hasn’t it happened?
Perovskites are promising, but real-world conditions have held them back.

Why China is still obsessed with disinfecting everything
Most public health bodies dealing with covid have long since moved on from the idea of surface transmission. China’s didn’t—and that helps it control the narrative about the disease’s origins and danger.

Anti-aging drugs are being tested as a way to treat covid
Drugs that rejuvenate our immune systems and make us biologically younger could help protect us from the disease’s worst effects.

A quick guide to the most important AI law you’ve never heard of
The European Union is planning new legislation aimed at curbing the worst harms associated with artificial intelligence.
Stay connected

Get the latest updates from
MIT Technology Review
Discover special offers, top stories, upcoming events, and more.