Select your localized edition:

Close ×

More Ways to Connect

Discover one of our 28 local entrepreneurial communities »

Be the first to know as we launch in new countries and markets around the globe.

Interested in bringing MIT Technology Review to your local market?

MIT Technology ReviewMIT Technology Review - logo

 

Unsupported browser: Your browser does not meet modern web standards. See how it scores »

{ action.text }

A clinical trial of Sirtris’s drug, SRT501, a potent version of resveratrol, a molecule found in red wine, has been suspended for safety reasons. The company, which was acquired by GlaxoSmithKline two years ago, is developing a number of drugs to combat the diseases of aging. The suspended trial was testing the drug for treatment of multiple myeloma, a blood cancer, in combination with Velcade, a drug that is already on the market.

According to Bloomberg:

Five of 24 patients in the trial developed cast nephropathy, a type of kidney damage that can stem from multiple myeloma and lead to organ failure, said Jo Revill, a spokeswoman for the London-based drugmaker.

However, SRT501 has previously been tested in two other trials for type 2 diabetes, without signs of this complication. It is in development for a number of diseases, including Alzheimer’s disease, obesity, and cancer.

A separate class of molecules under development at Sirtris, has also come under fire recently. These molecules, known as sirtuin activators, were named for their reported ability to activate SIRT1, an enzyme thought to play a crucial role in aging. As I noted in a previous blog,

The Pfizer study suggested that resveratrol, a compound found in red wine, and other molecules under development at Sirtris, don’t really activate this key enzyme and may not even have the life-extending benefits that have been reported by Sirtris founder David Sinclair and others.

3 comments. Share your thoughts »

Tagged: Biomedicine, aging, resveratrol, sirtris, GSK

Reprints and Permissions | Send feedback to the editor

From the Archives

Close

Introducing MIT Technology Review Insider.

Already a Magazine subscriber?

You're automatically an Insider. It's easy to activate or upgrade your account.

Activate Your Account

Become an Insider

It's the new way to subscribe. Get even more of the tech news, research, and discoveries you crave.

Sign Up

Learn More

Find out why MIT Technology Review Insider is for you and explore your options.

Show Me