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Scientists developing drugs to treat lupus face a daunting set of challenges. The disease, which affects 1.5 million Americans, results when the immune system mistakenly recognizes healthy tissues as dangerous and attacks them, touching off a range of responses. Some patients get arthritis and rashes, others develop heart disease, and some suffer kidney damage that can endanger their lives. And it still isn’t clear what causes all these symptoms.

Now two companies are working together to attack the disease with an experimental drug that tricks the immune system into behaving more normally. Results from phase II trials of the drug, called Lupuzor, showed a 53% improvement in symptoms among patients on the drug compared to a 36% improvement in those on placebo. That was enough to generate a tremendous amount of excitement leading up to the 9th International Congress on Systemic Lupus Erythematosus in Vancouver, British Columbia, which begins June 24. Lupuzor’s developers–ImmuPharma of London, U.K., and Cephalon of Frazer, PA–plan to release more detailed data from the trial during the conference.

Many drugs commonly used to treat autoimmune diseases, such as chemotherapy drugs, are known as immunosuppressants because they effectively shut down the entire immune system. Lupuzor, by contrast, is an immunomodulator–a drug that targets the specific immune cells involved in the disease. “In trials to date, we haven’t seen suppression,” says Peter Brown, vice president of clinical pharmacology and experimental medicine at Cephalon. That’s important because disabling the immune system entirely can cause unwanted side effects, such as dangerous infections.

Lupuzor targets T and B cells. In lupus, these immune cells malfunction, generating antibodies against proteins that healthy immune systems would normally ignore. Scientists at France’s National Center for Scientific Research split those proteins into smaller fragments and tested whether they might reverse the wayward immune response. One peptide was particularly effective in vitro, and in mouse models of lupus it significantly extended life. ImmuPharma, founded in 1999, led the early studies; Cephalon licensed Lupuzor in 2009 and is now in the early stages of planning a phase III trial.

The Vancouver conference should give physicians and scientists a more complete picture of how Lupuzor stacks up to other lupus drugs in development. Lupus experts have been paying particularly close attention to Human Genome Sciences’ Benlysta, a monoclonal antibody that targets B cells. The company is currently in phase III testing and is expected to release further details about its phase III results at the conference. So far, results have been impressive, with patients reporting significant reductions of “flares,” or bouts of debilitating symptoms.

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Tagged: Biomedicine, drug development, protein, immune system, immune response

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