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The researchers are also collaborating with ExxonMobil to overhaul algal cells into living fuel factories that would efficiently convert carbon dioxide into hydrocarbons that could be processed in refineries. “There are no existing cells that we’ve been able to find that do that process efficiently enough to make it economically viable,” says Venter.

Other potential applications include designing synthetic microbes that could purify water or manufacture chemicals or food ingredients. “I predict within a decade, any cell that’s used in industrial processes will be made synthetically,” says Venter.

To this end, the researchers plan to eventually develop a kind of universal recipient cell that could “boot up” any donor genome. The transplant process has proven to be the most technically challenging aspect of building a synthetic cell, says Venter, and it would be ideal to avoid a new round of troubleshooting for each new system that is developed.

For now, says Voigt, the biggest hurdle in realizing the potential of synthetic genomics is the gap between our ability to synthesize DNA and our ability to design it. “That’s going to be the next generation of research,” he says. “The technology around building DNA is mature now, and it’s going to be the toolbox to design it that comes next.”

Beyond practical applications, Venter also hopes that synthetic cells will help elucidate the basics workings of life, perhaps allowing researchers to decipher exactly what every component of a bacterial cell does. Although the genomes of countless organisms have now been sequenced, says Venter, we still don’t fully understand how even the simplest life forms function. “We want to try to make one of these cells the best-understood cellular system in biology,” he says.

Venter also points to what the cells–powered by genomes made in a lab from four bottles of chemicals, based on instructions stored on a computer–reveal about what life is. “This is as much a philosophical as a technological advance,” he says. “The notion that this is possible means bacterial cells are software-driven biological machines. If you change the software, you build a new machine. I’m still amazed by it.”

The development highlights the fact that we are moving out of the era where cells and DNA must be physically transferred from one location to another, says Voigt, to one in which biology is an information science. It would now be possible to sequence an organism’s genome in San Francisco, e-mail the sequence across the country, and bring that organism into being in a lab in Maryland. “Just the information alone is able to reconstruct that organism and convert it back into life,” says Voigt.

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Credit: Science/AAAS

Tagged: Biomedicine, genetics, bacteria, synthetic biology, Synthetic Genomics, Craig Venter

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