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Go to the emergency room with chest pains, and physicians can determine fairly routinely–with blood tests and an electrocardiogram–whether or not you’ve had a heart attack. A bump to the head is another matter. Currently, no blood tests are approved as a way to diagnose brain injury in the United States. In the case of mild head injuries or more serious ones that take time to develop, it’s difficult to tell early on how severely a patient has been hurt and whether she will suffer long-term consequences.

The high-profile case of actress Natasha Richardson, who died last month after a seemingly minor fall on the ski slopes, demonstrates this uncertainty in a dramatic fashion. According to news reports, she was walking and talking after the fall and refused medical attention, but later developed a headache and was rushed to the hospital. Richardson died two days later of an epidural hematoma, an injury in which blood builds up between the brain’s outer membrane and the skull.

One of the most challenging situations for physicians is deciding how to deal with patients who come into the emergency room with mild traumatic brain injury or concussion. Those with telltale symptoms such as dizziness and nausea will be given a computed axial tomography (CT) scan to look for signs of bleeding in the brain; patients who do show bleeding will need further monitoring and sometimes surgery. But because it’s difficult to determine who needs the scan, many patients get it unnecessarily, and others who do need it may be sent home.

Scientists hope that a blood test to detect proteins and other molecules released into the blood after brain injury could help. But developing such tests has been a challenge. “It’s very hard, because not every head injury is the same,” says David Hovda, director of the Brain Injury Research Center at the University of California, Los Angeles. “Getting hit in the forehead or rotating the neck damage different parts of the brain. And men and women, young and old, people who come in drunk, can all show brain injury differently.”

One blood test already used in Europe to screen head-trauma patients before CT scans detects a protein called S100B, which is released by astrocyte cells in the brain after injury. “The thinking is, if you don’t have [this marker] in the blood, then you don’t have the kind of brain injury you could see on CAT scan,” says Jeffrey Bazarian, an emergency-room physician and scientist at the University of Rochester Medical Center, in New York. The test is not approved for use in the United States, however. In a set of clinical guidelines for evaluating head trauma published recently, Bazarian and others estimated that the S100B test could significantly reduce unnecessary CT scanning. “We predict it could eliminate unnecessary radiation in a lot of people–about 30 percent [of those who come into the ER with brain injury],” he says.

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Credit: (Brain) University of Wisconsin and Michigan State Comparative Mammalian Brain Collections and the National Museum of Health and Medicine.

Tagged: Biomedicine, brain injury, biomarkers, blood test, TBI, concussions

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