Select your localized edition:

Close ×

More Ways to Connect

Discover one of our 28 local entrepreneurial communities »

Be the first to know as we launch in new countries and markets around the globe.

Interested in bringing MIT Technology Review to your local market?

MIT Technology ReviewMIT Technology Review - logo

 

Unsupported browser: Your browser does not meet modern web standards. See how it scores »

{ action.text }

About eight to twelve million years ago, the evolutionary ancestor to humans, chimpanzees, and orangutans appears to have undergone a burst of evolution, driven by duplicated sequences of DNA. This mechanism of genetic change, which has only recently come under scientific scrutiny, may have endowed primates with an evolutionary flexibility that drove the development of different great ape species, including humans.

When a stretch of DNA is mistakenly duplicated, extra copies of the gene or genes within that region are added to the genome; those genes can then mutate separately. “Duplications are really important from an evolutionary perspective because they add a lot of variation to the genome,” says Tomas Marques-Bonet, a scientist in Evan Eichler’s lab at the University of Washington, in Seattle, who led the research. “These regions are rapidly evolving.”

Most estimates of genetic similarity between humans and other primates have focused on single-letter changes to the genome as the primary basis for evolutionary change. But scientists are now discovering the importance of structural changes to the genome, which include deletions or duplications of segments of DNA between 1,000 and 100,000 letters in length. These regions are flanked by repetitive stretches that are thought to trigger errors in the cells’ DNA replication process, resulting in duplicated genes.

“It’s only recently that we have had the sequence data and the genomic tools to study this and understand its role in evolutionary history,” says George Perry, a scientist at the University of Chicago, who was not involved in the research. The chimp genome was released in 2005, and the orangutan and macaque genome projects are ongoing. In addition, scientists can now create custom-designed gene microarrays to quickly detect a large number of specific duplications.

Marques-Bonet and his colleagues analyzed the genome sequence of four primate species: humans, chimpanzees, orangutans, and macaques. Humans, chimps, and orangutans descend from the African great ape lineage, sharing a common ancestor about 12 million years ago, while macaques, classified as old-world monkeys, split from the common primate lineage more than 25 million years ago. Comparing areas of DNA duplication in the genome sequence, researchers found a burst in the rate of duplications right before orangutans split from the tree, and a second burst before chimps and humans diverged, according to research published today in the journal Nature. This increase happened even as rates of single-letter changes decreased.

Scientists are hesitant to speculate about precisely how the acceleration in the rate of duplication arose in the human and chimp lineage, and how it affected human evolution. For example, it’s not yet clear whether the duplications that occurred during this time period conferred an evolutionary advantage on their bearers. “We think that duplications make the genome more dynamic,” says Marques-Bonet. “But having a dynamic genome creates both sides of the coin: these rearrangements can be beneficial, or they can be linked to disease.” Recent research shows that duplications in the human genome play a role in a variety of diseases, including autism, schizophrenia, and mental retardation.

11 comments. Share your thoughts »

Credit: Macaque, Scott Liddell; Orangutan, Tom Low; Chimpanzee, Aaron Logan; Charles Darwin, Julia Margaret Cameron

Tagged: Biomedicine, DNA, genome, evolution, gene expression, copy number variation, primate, DNA deletion, genetic diversity

Reprints and Permissions | Send feedback to the editor

From the Archives

Close

Introducing MIT Technology Review Insider.

Already a Magazine subscriber?

You're automatically an Insider. It's easy to activate or upgrade your account.

Activate Your Account

Become an Insider

It's the new way to subscribe. Get even more of the tech news, research, and discoveries you crave.

Sign Up

Learn More

Find out why MIT Technology Review Insider is for you and explore your options.

Show Me