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There is ample evidence that a severe low-calorie diet can increase longevity in a number of animals, including flies and rodents. But does it work in humans? Scientists at Washington University in St. Louis are hoping to answer that question by studying a group of people – 35 members of the Calorie Restriction Society – who eat around 1,800 calories a day in an effort to improve their health and extend lifespan.

It will be years before the study, which began four years ago, determines how the diet affects lifespan. But John Holloszy and his collaborator Luigi Fontana have already found that those following such a calorie-restricted diet – they call themselves “CRONies” (Caloric Restriction with Optimal Nutrition) – are protected against some diseases associated with aging, such as cardiovascular disease and Type 2 diabetes. The researchers are now planning a larger trial, in which people eating an average diet will reduce their caloric intake by 25 percent, to determine how caloric restriction leads to biological changes over time.

Holloszy talked with Technology Review about his current findings at the 35th annual meeting of the American Aging Association in Boston this week.

Technology Review: What’s the most striking finding you’ve seen in those following a calorie-restricted diet so far?

John Holloszy: They are powerfully protected against the diseases of old age, such as heart disease. They have low levels of cholesterol and triglycerides and extremely low blood pressure – similar to a young child, around 100/60. As a result of the low blood pressure, they have less strain on the arteries, which are much more elastic than usual for people of their age. Their hearts resemble the heart of a person 17 years younger. They also have very good insulin sensitivity, so they are not going to get Type 2 diabetes.

TR: What about their levels of inflammation? That is another factor that’s been the focus of a lot of aging research in the last few years.

JH: As we get older, we get an increasing amount of inflammation, which is probably a very important part of the aging process. CRONies have very low levels of inflammation. C reactive protein, for example, is a marker and cause of inflammation. An average value for a middle-age person is about 2.5; but CRONies have levels of 0.2. It’s just amazing.

TR: So are these people going to live longer?

JH: Caloric restriction definitely does slow secondary aging, which is linked to lifestyle and disease. Smoking, for example, causes secondary aging of the lungs and skin. It’s impossible to say if they’ll increase their maximum lifespan. But I’m sure they’ll live longer than they would if they didn’t do caloric restriction.

TR: You also compared them to a group of runners to see how caloric restriction measures up to exercise.

JH: Yes. We studied a group of master athletes, who are the thinnest group of people eating regular diets that we could find. They were very lean, but not as thin as the CRONies. It’s hard to find anyone that thin, unless they’re sick.

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