In 1798, the English economist Thomas Malthus argued that population increases geometrically, outstripping the arithmetic growth of the food supply. He promised "famine ... the last, the most dreadful resource of nature." It took another 125 years for world population to double, but only 50 more for it to redouble. By the 1940s, Mexi­co, China, India, Russia, and Europe were hungry. Franklin D. Roosevelt's farsighted vice president-elect, former secretary of agriculture Henry A. Wallace, believed the solution lay with technology. He was right: the Malthusian tragedy never happened, chiefly because Norman E. Borlaug transformed the breeding of wheat, which feeds more people than any other crop.

From 1939 to 1942, Mexico's harvest was halved by stem rust, a fungus whose airborne spores infect stems and leaves, shriveling grains. Anxieties about wartime food shortages led the American philanthropic organization the Rockefeller Foundation to create the country's first foreign agricultural program: the Coöperative Wheat Research and Production Program, which was based in Mexico and which Borlaug joined, as its plant pathologist, in 1944. The program was prescient: rust hit the North American breadbasket in 1954, wiping out 75 percent of the durum wheat crop used for pasta.