The pharmaceutical industry has a drug problem: it can't find enough new ones. Companies are under pressure to invent the next Prozac or Viagra, but without more efficient and cost-effective ways to develop new drugs, those kinds of blockbuster medications will remain once-in-a-decade discoveries. "It costs too much, it takes too long and it produces too little," says Rod MacKenzie, a vice president in Pfizer's Global Research and Development division, of the industry's traditional method of drug discovery. "The problem is, how do you change the engine while the vehicle is still moving?"

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