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July 1998

New Starring Roles for Collagen

Structural insights could expand uses

By Rebecca Zacks

Animals are cut from a cloth woven largely of collagen. This rope-like protein is the most abundant in the body, giving structure to tissues such as skin and cartilage, but to date chemists haven't fully understood the source of collagen's strength. A prevailing theory dictated that the molecule-a tightly wound triple helix-was braced by a scaffolding of water molecules. But research from the University of Wisconsin-Madison points to a different answer, one that not only helps explain collagen's properties, but also might eventually expand the protein's utility in cosmetic surgery, wound healing and perhaps even arthritis diagnosis and treatment.

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