TR Editors' blog

Failed Diet? You Really Can Blame It on the Genes

A fruit fly study shows that genetics have a profound effect on how animals respond to diets.

Emily Singer 08/02/2010

  • 6 Comments

A study of genetically diverse flies may help explain why some people can eat a steady diet of junk food and stay skinny, while others quickly gain weight. Researchers put 146 genetically distinct strains of fruit flies on each of four different diets--a nutritionally balanced diet, a low calorie diet, and high fat or high sugar diets--and then measured body weight and other metabolic traits.

According to the findings, published last month in the journal Genetics, some flies were highly sensitive to the different diets, while others maintained the same weight regardless of what they were fed. Diet alone contributed very little to variability in weight. Instead, genetics and the interaction between genetics and diet played a major role.

The findings could give you an easy excuse for failed diet attempts. According to a statement from the Genetics Society of America, "This study strongly suggests that some individuals can achieve benefits from altering their dietary habits, while the same changes for others will have virtually no effect."

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mergatroid

24 Comments

  • 554 Days Ago
  • 08/03/2010

Stress test those flies

All those flies should have also been inside an environment where moments of stress disrupt normal metabolism. All cows and chickens become fattened when living their lives inside the farm fed environment. No chicken or cow remains skinny because of their genes. Stress any of these farm fed cows and chickens, and also those flies in this experiment and trip up some real genetically induced responses to watch for.

Good article, Ms. Singer.

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cshepherd6

1 Comment

  • 529 Days Ago
  • 08/28/2010

Re: Stress test those flies

Agree

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resonator80

2 Comments

  • 554 Days Ago
  • 08/03/2010

Failed diet, genes and failed research

This article (and the reported research) fail any common sense test. If the fruit flies (or any other animal) are fed nothing, they will lose weight. Yes, there will be metabolic differences, but there are limits to metabolic efficiency.

So the "low calorie" diet on which some fruit flies maintained weight was not low calorie enough. Cut the rations by another factor of two and see what happens.

For the application of low calorie diets to humans, please see the Tech Review articles by Richard Muller, "The Physics Diet" (http://tiny.cc/0xoab ) and "The Physics of Gluttony" (http://tiny.cc/trr18 ).

Bill Edelstein
Baltimore, MD

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vmyev

4 Comments

  • 554 Days Ago
  • 08/03/2010

Re: Failed diet, genes and failed research

Bill, thanks for pointing me to Richard Muller's articles - must have missed them when they came out.  I certainly agree with Richard and have been proselytizing the same approach to anyone who would listen for many years.  I guess I'm one of the fortunate fruit flies - my weight has been 165 +/- 5 pounds since high school (I'm just shy of 65 today).  I don't pay particular attention to what I eat or to my activity level, but recently have dropped dinner in favor of a beer and some peanuts (sleep better that way!).

I have many friends who are fat, even obese.  Most  of them are OK with the way they are, and who am I to tell them otherwise?  The sorriest people, in my opinion, are the ones who are obese, wish they were like Twiggy, but don't have the guts to do anything about it!

I don't blame the genes, since we are all complex chemical factories - with many similarities, but many differences.  I blame the one area in which America truly leads the world:  marketing.  We can sell refrigerators to Eskimos and Twinkies to 300-pound behemoths!

Perhaps the answer to our health care dilemma is to ease off on smokers and focus on the 60% of America's population which is obese.  They are clearly as sick as the smokers. 

Maybe we should consider selling airline tickets and restaurant food by the pound.

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pmdulaney

16 Comments

  • 553 Days Ago
  • 08/04/2010

Re: Failed diet, genes and failed research

I read Dr Muller's article when it first came out and he does make some good points, but he admits that his model is overly simplified. People who have never had a hard time keeping weight off typically are the ones who credit their will power for their low weight. The book Good Calories, Bad Calories by Gary Taubes argues 1) Not all calories are the same; and 2) (As this article shows) not all metabolisms are the same. There are some people who are extremely hungry unless they are obese. Their bodies will not burn fat (and relieve the sense of hunger) until their percent body fat reaches a certain level. In many cases the obese can change their situation dramatically by eliminating processed sugar and refined carbohydrates from their diets, but others can only achieve normal weight by making their bodies literally starve. I am somewhat overweight myself (6'1'', 210 lbs) and I agree that I could and should lose 10 - 15 with the moderate level of hunger pangs that Muller talks about. But having read Taubes's book has made me less judgmental toward the obese.

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resonator80

2 Comments

  • 527 Days Ago
  • 08/30/2010

Re: Failed diet, genes and failed research

I certainly agree that we should not be judgmental toward overweight people--we should be concerned for their health. Overweight stresses many body organs (heart, pancreas, joints). In any case, it is not a good idea to keep nagging.

As far as I can tell, Richard Muller is fundamentally correct. All the diet books in the world (including the one by Taubes) are aimed at telling people how to lose weight without experiencing the hunger that is unavoidably part of that process.

OK, "good" calories may be found in food that has more nutritional value than food containing "bad" calories. But calories are just a measure of energy, and overweight is caused simply by too many calories.

Bill Edelstein
Baltimore, MD

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