TR Editors' blog

Baby Screened to be Cancer Gene Free

An event making headlines in Britain is already happening under the radar in the US.

Emily Singer 01/09/2009

  • 2 Comments
An eight cell embryo ready for biopsy. Credit: The Infertility Center of St. Louis

The first baby in Britain to have been screened as an embryo for a genetic variation, called BRCA1, which greatly raises risk of breast cancer, has been born, according to recent news report. Because several members of the infant's father's family had been diagnosed with breast cancer at a young age, the parents decided to undergo IVF and screen their embryos for the mutation before implanting them.

The decision was a controversial one, raising arguments that this type of screening is one step on a slippery slope towards eugenics. Pre-implantation genetic diagnosis, as the procedure is called, has traditionally been limited to genetic disorders known to be fatal. But as the number of known disease-linked genes grows, so do the options for testing. BRCA1 raises a women's risk of developing breast cancer to about 80 percent, but does not guarantee that she will develop the disease.

The event has garnered extensive press in the UK, where in vitro fertilization is highly regulated; the governing body that oversees fertility only recently voted to allow this kind of screening. But in the US, where reproductive technologies are largely unregulated, such cases may already be occurring regularly. A fertility specialist I spoke with for a review published in the March 2007 issue of TR, said his lab had tested embryos for more than 150 diseases or risk genes, including the BRCA1 variant.

Little data exists on the rates of this type of testing in the U.S., one of the few developed countries with so little regulation. Sex-selection, for example, is not outlawed, though most fertility clinics say they consider it ethically questionable and decline such requests. Any disease or trait for which a genetic risk factor has been identified--one that predicts athletic prowess, for example--could theoretically be screened for, and the number is growing daily.

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phoenix

172 Comments

  • 1125 Days Ago
  • 01/14/2009

the final frontier

The relentless, so called progress, being made in the field of genetic manipulation, is heading at breakneck speed fast towards one inevitable destination. And that objective is to redesign various key aspects of the human DNA enough to the point where it can start to mutate into an entirely different species. Although this subspecies of homo sapiens, will, in the beginning, still bear a resemblance to us, those traits will eventually disappear. The reason that this is being done, albeit subconsciously, is so that our progeny will be able to adapt to the harsh conditions of extraterrestrial travel and the inevitable colonization of other planets. There will be a huge hue and cry, a momentous social struggle to prevent it from happening, but this radical transformation of our physiology is going to take place. It's just a matter of time.

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shomas

245 Comments

  • 1107 Days Ago
  • 02/01/2009

Genetic screening and the self-direction of human evolution

There is an obvious evil when eugenics is practiced by governments. When government decides which individuals will be winners or losers in the game of passing on ones genes.

But when individual parents use genetic screening for genetic predisposition to disease of pre IVF embryos, they may increase their chance of passing on their genes. Arguably raising a child involves a huge investment of effort. Limiting ones family to health risk and the associated cost to ones family maximizes the chance ones genes will pass on to the next generation and the next.

Individual parents using genetic screening is not the same as governments eradicating entire races. 

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