TR Editors' blog

Cooling the Brain

A new technique sheds light on the neurological basis of complex behavior.

Emily Singer 11/12/2008

  • 4 Comments

Scientists at MIT have developed a novel way to selectively cool parts of the brain, slowing them down and shedding light on the function of that particular spot. In a study of songbirds, which are often used as an experimental model of human speech, cooling part of the brain known as the HVC slowed the birds' songs. Play the videos below to hear a sample song with and without cooling.

According to a press release from MIT,

The song slowed in proportion to the degree of cooling, with the biggest temperature change (a 10 degrees Celsius reduction) causing the song to stretch out by around 30 percent.

Not only did the overall duration of the song increase, so did each individual syllable, so the overall rhythmic structure was preserved without changing the sounds within the song. The effect can be compared to a music box or piano roll. Rotating the drum more slowly slows the tempo of the music without affecting individual notes.

Following this analogy, HVC corresponds to the mechanism that turns the drum; cooling it is equivalent to reducing the speed of rotation.

Michale Fee and his colleagues created the cooling device using technology similar to that used in portable electronic beverage coolers. They say that it could be used to study other complex behaviors, such as walking or swimming.

"We can also use this cooling technology to discover which brain regions control the timing of different complex behaviors in different animals, something that has been very difficult to assess until now," Fee said in the release. "We know that HVC is related in some ways to [the] human cortex, so it could be showing us a very general mechanism for representing the passage of time within the brain."

The research was published today in the journal Nature.

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nekote

139 Comments

  • 1187 Days Ago
  • 11/14/2008

How is the cooling done?

How is the cooling done?
Invasive / surgery / a probe?
Non-invasive?

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weisen

1 Comment

  • 1182 Days Ago
  • 11/19/2008

Re: How is the cooling done?

It appears from the original article that the cooling was done via an implanted probe.

http://www.nature.com/nature/journal/v456/n7219/abs/nature07448.html

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nekote

139 Comments

  • 1187 Days Ago
  • 11/14/2008

Applicable to human brain study?

Is the technique likely to be applicable to human brain study?

Likely to be more or less useful, in any particular aspect of brain function - cognition, speech, vision, language, emotion, mental illness, ... ?

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Silva

1 Comment

  • 1072 Days Ago
  • 03/09/2009

Re: Applicable to human brain study?

This methodology might have a great usefulness to study timming of speech in the brain of people who stutter.

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