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Can Aging Be Solved?

Continued from page 1

By Emily Singer

Wednesday, July 01, 2009

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TR: You have often pointed out that even in the research world, there is great confusion over the meaning of the term "aging." What is the confusion?

LH: The facts are these. There are four aspects to the finitude of life: aging, longevity determination, age-associated diseases, and death. Aging is what we call a catabolic process--the breakdown of molecules. Longevity determination is the reverse--the repair or maintenance of molecules. Aging gets confused with longevity determination. The aging process increases vulnerability to age-associated diseases. These concepts are distinguishable from each other and fundamentally different.

TR: Why is it so important to distinguish between aging and the diseases of aging?

LH: You cannot learn about the fundamental biology of aging by studying disease processes. Resolving age-associated diseases tells us nothing about the fundamental biology of aging, just as the resolution of childhood diseases, such as polio and childhood anemia, did not tell us one iota about childhood development.

TR: Why, then, is it important to do research on the fundamental processes of aging?

LH: Because the fundamental processes of aging increase vulnerability to all age-associated diseases. That is why cancer, cardiovascular disease, and stroke, the three leading causes of death in developed countries, occur in older age. The root cause of age-associated diseases implies--demands, even--that for anyone to understand the causes of age-associated diseases, they should know something about the fundamental processes of aging. Learning something about why old cells are more vulnerable to pathology is a key question for which we have little research being conducted.

TR: Really? Little research is being conducted in this area?

LH: Essentially, less than 3 percent of the budget of the National Institute on Aging, the key source of major funding in this country for research on aging, is spent on studying the fundamental biology of aging--and that's a liberal estimate. Over 50 percent of its budget is devoted to Alzheimer's-disease research. I am not arguing that we stop research on Alzheimer's. I'm simply pointing out the fact that there is an enormous difference between research on aging and age-related diseases. If you cured Alzheimer's tomorrow, it would add about three weeks on to the average life expectancy in this country.

TR: Would focusing more funding on research on the fundamental process of aging bring a greater return on the investment?

LH: Absolutely.

Comments

  • Backwardness of Logic
    TR: So it doesn't imply that there is a solution to aging?
    LH: Why would you want to do that?
    # what?!
    TR: Some people would like to slow or halt the aging process.
    LH: They haven't thought about the consequences. We relate to each other by perceptions of differences in age, which would be destroyed if some chose to increase their longevity and some did not.

    # Yes it would, that is what disruptive innovations do. And incidentally, why would you want to keep the status quo?


    People who say they want extended longevity say they want it to be so when life satisfaction is greatest.

    # That's one of the reasons but not the most important one as you picture it here. How about we take the lost of one's loved ones for a reason. Have you given thought to the horrible trauma that people go through as a consequence of losing someone and the enormousness of its impact on people's life?
    I think you have got this all backward.

    Yet they won't know [when that is] until late in life.

    # Backwards again… yes, it is true that nostalgia comes to you when you have lost something but if you never get to lose it then there is no reason to be nostalgic about it. If I never get to be old I would not have any perception of being old and losing my youthfulness and therefore I would not miss it. Why would I? It would not even cross my mind is it will be nonexistence.

    darwinskerne...
    07/01/2009
    Posts:1
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    • Re: Backwardness of Logic
      Dr. Hayflick reminds me of Einstein commenting on God not playing dice to discredit quantum physics.

      A father of the field tries to "hold your horses."

      Also, I didn't like his car analogy.  The body is self-repairing.  Various human cells have been immortalized.  There are all sorts of reasons why that analogy is specious.

      Aside from all the many reasons we should try to extend life:

      1)  People can invest more in achieving and employing great capabilities and skills that may require decades to master, resulting in all the greater realization of human potential
      2)  There will need no longer be a tradeoff between wisdom and vigour
      3)  Old folks can be happy and productive, rather than bored and burdensome
      4)  If we do not respect life to the extent of focusing on its preservation, then what moral claims do we possess?
      5)  As with Everest, because it is there to be conquered.

      mikey248
      07/08/2009
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  • hmmm...
    There seems to be a great deal of 'faith' in Dr. Hayflick's views on the inevitabililty of ageing...an holistic 'correctness' to death simply because people have always been born, lived and died. He says those who would extend life 'haven't thought it through'. I completely disagree. Just because we can't predict what will happen if people suddenly start to live longer doesn't mean no one has thought about the ramifications. Just because we can't predict the future doesn't mean catastrophe is certain.

    avacoder
    07/01/2009
    Posts:1
    Avg Rating:
    4/5

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