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In this image, each vertical bar represents an individual, and each element of European ancestry is represented by a color: Basque (purple), Spanish (yellow), southern European (red), continental European (green), and northern European (pink). The mix of colors within an individual bar represents the proportion of each of five possible ancestries in the analysis. The Greeks, for example, mostly have markers linked to southern Europeans, with a few markers affiliated with Northern Europeans and continental Europeans. The neighboring Italians have a more varied profile, with some individuals having significant numbers of markers linked to the Basque and northern European populations. The Germans and east English also have a varied profile, possessing markers linked to all five groups.
Marc Bauchet and Mark Shriver
In a study published last year, Mark Shriver and his team at Pennsylvania State University analyzed 10,000 genetic markers in nearly 300 people of Armenian, Jewish, Greek, Spanish, Basque, French, Italian, German, English, Irish, Polish, and Finnish descent. They found that genetic profiles differed from north to south and east to west. "Genetic displays seem to fit with geographic features of a map," says Shriver, who is also a consultant for DNAprint, a genetic-testing company in Sarasota, FL. For example, the Iberian Peninsula, isolated from the rest of Europe by the Pyrenees, seems to harbor a distinct genetic profile.And areas in the middle of Europe have a profile somewhere between that of the north and the south.
Two companies have already condensed those findings into commercial tests: DNAprint and 23andMe, a personal-genomics startup based in Mountain View, CA. DNAprint's European service uses a subset of 1,349 genetic variations from the original 10,000 to classify an individual's ancestry according to five groups: southeastern European, Iberian, Basque, continental European, and northeastern European. 23andMe, which offers ancestry analysis as part of a broader genetic screening service, estimates users' genetic similarity to 14 different populations around the world, including northern and southern Europeans.
Consumer ancestry testing, however, remains far from exact. All genetic ancestry tests are probabilistic: while individual markers might be more likely to appear in certain populations, that is not always the case, meaning that not everyone who carries that variation has ancestors in that group.
And the profile that a particular service spits out depends on the database used to calculate it. DNAprint offers a $240 global ancestry test, AncestryByDNA 2.5, that analyzes 176 markers derived mainly from studies of four groups: Native Americans, East Asians, West Africans, and Europeans. Because those groups have contributed most heavily to the current U.S. population, the test works best for people in the States.
It may generate false results for people in other parts of the world. For example, some Europeans who took the test were deemed to have Native American ancestry. "That's ludicrous," says Mark Stoneking, a geneticist at the Max Planck Institute for Evolutionary Anthropology, in Germany. "It's most likely picking up central Asian ancestry, because there is no central Asian ancestry in the databases."
California's actions are likely just the beginning of a regulatory debate.
DNA tests to find out your ancestry are growing in popularity. But do they really work? And are they worth it?
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lkrndu
36 Comments
History
I wonder how much European history Michael Seldin has studied? (Actually, I imagine he's up to date, that was just to get your attention. :)
But he says that genetically he can't tell Greeks, Italians, or Spaniards apart genetically.
Why should they be so different? Italy was the crossing point between the three regions for a very long time. Note the prevalance of Spanish surnames in Italy and the Spanish control of most of north Italy for quite a long period, and the spread of Greek culture and architecture across south Italy and Sicily.....
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phoenix
172 Comments
Re: History
Not that it amounts to much, but I knew a second generation Polish-Canadian girl who had a distinct Oriental slant to her eyes, a genetic trait which I assumed had been passed onto one of her predecessors when the Mongols swept across Europe and 'intermingled' with the indigenous Slavic population. Although the Mongols had been united under the iron rule of Ghengis Khan, who died in 1227, his reputation for cruelty to his enemies was carried on by his son Ogotai, who pursued a familiar rapacious campaign of pillage and plunder throughout Hungary and Poland up until 1241.
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