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More Effective Alcoholism Treatment

New drugs could bring treatment to a much broader set of patients, says a leading expert on alcohol abuse.

By Emily Singer

Friday, October 27, 2006

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New research is fundamentally changing our understanding of both addiction and recovery. Dozens of new alcoholism medications are in preclinical or clinical testing; many of them target novel pathways, such as the exaggerated stress response that both humans and animals develop under the influence of alcohol addiction, an amped up version of the typical release of adrenaline and other chemicals when we perceive a threat.

But neither new treatments nor existing drugs are making their way to enough patients, says Mark Willenbring, director of the Division of Treatment and Recovery Research at the National Institute on Alcohol Abuse and Alcoholism. An antirelapse drug called naltrexone, for example, was approved in the 1990s but is prescribed for only about four percent of those with alcohol dependence. It blocks the brain's reward mechanisms, which are often triggered by drinking.

Willenbring is promoting a new system, in which patients are treated by their primary-care doctors in office visits. He says this model will appeal to people who either don't want or don't need lengthy counseling or inpatient programs. Willenbring spoke with Technology Review about what works in treating alcohol addiction.

TR: What's the biggest problem with the treatments for alcohol dependence available today?

MW: The number-one problem is that so few people with alcohol dependence actually get treatment. Over the lifetime, it's probably fewer than 10 percent.

TR: Why so few?

MW: Most people say they don't need treatment, or that they can handle it on their own.

Part of the reason for that is the interaction between the treatment system and the perceived need for treatment. For example, if the only treatment for depression is to be hospitalized when seriously depressed and to undergo electroconvulsive therapy, that's a high threshold. Most of us would have to be really badly off to go get that. But if treatment meant getting a prescription from your family doctor, that's a much lower threshold. Before that [became available], very few people with depression got treatment, because the treatment was so draconian.

The treatment system we currently have [for alcohol dependence] is separated from mainstream health care and mainstream mental-health care. It was devised in 1975, when all we had for treatment was basically group counseling and AA. So when people think about getting treatment for drinking, they envision going somewhere like the Betty Ford Center.

That system has three main problems: First, most people don't want it; they have to be forced into it. The second problem is that patients within the general health and mental-health system are not getting located or treated. Third, because the programs are built around counseling, they are not staffed by medical personnel. So there's no one there to talk about medications available for treating alcohol dependence. And a lot of counselors don't really believe in [medication].

Consequently, the new treatments we're developing are not being implemented. Try finding a doctor who knows how to prescribe naltrexone for alcohol dependence. They're very hard to find.

Comments

  • Pyroluria
    It is estimated that 40% to 80% of alcoholics are pyroluric.  This means they retain copper and excrete zinc and B-6.  This results in high anxiety, which results in them self-medicating with alcohol to calm the anxiety.

    Just supplementing with zinc and B-6 removes the anxiety, and then there is no need to self-medicate.

    Most doctors don't even know about pyroluria, but you can find quite a bit of info about it on the web.
    Rate this comment: 12345

    Hoss
    10/27/2006
    Posts:1
    Avg Rating:
    5/5
    • Re: Pyroluria
      Since alcoholism can cause severe nutritional deficiency, so during <a
      href="http://www.thewatershed.com/">alcohol treatment</a> it's good to supplement with not
      just the ordinary One-A-Day kind vitamin pills, but also larger, but safe doses of Zinc and the Vitamin B Complex to support the brain and nervous system.
      Rate this comment: 12345

      durdana
      12/13/2006
      Posts:1
    • Re: Pyroluria
      Hi,
      Myself Jimmy from Canada. Thanks for the wonderful and useful information.
      Alcoholism Information
      Rate this comment: 12345

      hari001
      02/18/2009
      Posts:1
  • alcoholism
    In Nov., I will celebrate my 39th anniversary as a full member of AA. In those years, there have been many suggestions for "curing" alcoholism, including program suggested by RAND Corp.

    None has held up. AA is a great deal more than counselling; it is a fellowship, one to which a large number of public figures are happy to belong.

    There have been other medical modalities; they cannot cure what is "different" about alcoholics
    Rate this comment: 12345

    virgiehl
    10/28/2006
    Posts:1
  • Anti-craving medications
    All current medications for alcoholism will only address the craving for alcohol in the initial stages of treatment. None of these medications are designed to cure alcoholism, nore do the manufactirers or medical profession claim a cure.

    A psychiatrist and long time alcohol treatment specialist, Dr. Abraham J. Twerski, recently defined alcoholism; "Alcoholism is in fact a symptom. It is a symptom of the absence of spirituality, and the treatment is the development of spirituality."

    He went on to say that that is why Alcoholics Anonymous was so successful with over 2,500,000 members, because AA restores the person to a ethical/moral/spiritual course of action. In doing so the alcoholic finds what he was always looking for - freedom to do as he pleases without alcohol.

    Robin Foote BriefTSF.com
    Rate this comment: 12345

    Ramdaro
    10/29/2006
    Posts:1
    • Re: Anti-craving medications
      'Spirituality'??? As a cause of (as in lack thereof)and a cure for(as in gaining some), alcoholism?

      Pray *what*?!

      Reguardless of the researcher's credentials (I'd be interested to learn those) but also lacking a link to papers etc. I think this one of the silliest remarks I've read for a long time.

      Do the words 'genetic propensity' mean anything to you?
      Rate this comment: 12345

      Islander
      10/31/2006
      Posts:1
      Avg Rating:
      5/5

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