Since 2000, the U.S. Food and Drug Administration has reported a general decrease in the number of new molecular entities -- drugs with new chemical structures -- submitted for approval each year, indicating a decline in the discovery of new drugs. Thirty-six years ago, pharmaceutical professionals also worried about drug discovery and lamented a decline in the rate at which new drugs were reaching the U.S. market. In December 1970, Technology Review published "Drugs: Has the Age of -Miracles Passed?...and Will That of -Science Ever Dawn?" It was a two-part review of a symposium on drug discovery at the American Chemical Society's national meeting that year. Barry M. Bloom, a representative from Pfizer, presented data, summarized in the bar graph shown here, demonstrating a decline in the rate of drug discovery.

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