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Thursday, April 10, 2008

A Fuller Picture of Your Lungs

Continued from page 1

By Katherine Bourzac

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Lung check: Images of the lungs of a healthy subject taken in the Harvard MRI system show the regional concentrations of oxygen when lying down (left) and sitting up (right).
Credit: Matthew Rosen/Harvard-Smithsonian Center for Astrophysics

In Rosen's imager, the magnetic field is generated by two coils mounted on what look like two metal garden trellises. Wire grids and rings in these structures direct the field towards a person lying, standing, or sitting up in the center. (In conventional MRI machines, a cylindrical magnet that surrounds the supine patient produces the strong magnetic field.) The subject wears an antenna over his or her chest that consists of a cardboard tube wrapped with a coil of wire and coated in rubber. After inhaling a mixture of polarized helium and air through a tube, the subject must sit still and hold his or her breath for up to 30 seconds while the antenna picks up the magnetic spin of the helium in the subject's lungs. Rosen says the system cost less than $100,000 to build.

In their imager, Rosen and Walsworth can see the position of helium atoms in a subject's lungs. Oxygen molecules influence the spin of the polarized helium, so the Harvard system can also visualize the concentration of oxygen in the lungs. If it's high in one region of the lung, oxygen isn't being absorbed well and the subject may have poor lung function.

There are several other groups using polarized gas to create MRI images of the lungs, says Driehuys. But all the other groups use expensive, commercially available MRI systems. What makes Rosen and Walworth's work unique, Driehuys says, is that they've built their own cheap, low-power MRI scanner.

The Harvard-Smithsonian researchers are now adapting their system to shorten the time needed for imaging. "You do have to stay still and hold your breath," says Rosen, which can be difficult for people with compromised lung function.

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Comments

  • A Fuller Picture of Your Lungs
    rdvandell on 04/10/2008 at 3:47 PM
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    Hey, fantastic work!!

    Unfortunately, "Radiologists" continue to state they do not understand MRI well enough to support it in favor of X-Rays.

    I propose having the "Radiologists" stand outside the shield wall during procedures. Do that and you'll see MRI replace X-Rays in a tick.
    Rate this comment: 12345
    • Re: A Fuller Picture of Your Lungs
      lmwong on 04/11/2008 at 7:15 PM
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      I'm sorry, but that image looks nothing like the MRIs I interpret as a "radiologist". This group is looking at a functional component of the lungs, rather than an anatomical component, much more like a nuclear medicine VQ scan, which gives you very similar nonspecific images to reveal areas of ventilation vs perfusion. An MRI unit is huge and vastly more expensive than an x-ray unit. An x-ray will take a second to do, while an MRI can take minutes to hours. With the number of x-rays done during a day, there's no way an MRI can ever replace x-rays. For bread and butter medicine, an MRI will not give you more information than a simple x-ray will. Some people with metal in their body cannot have MRIs done. The radiation dose of 1 chest x ray equals 10 days of background radiation you get living at sea level. We "radiologists" and radiology technicians stand behind shielded walls because we take hundreds of these x-rays a day, every day of our lives.
      Rate this comment: 12345
      • Re: A Fuller Picture of Your Lungs
        Katherine Bourzac on 04/14/2008 at 12:42 PM
        Technology Review TR Staff
        Associate Editor
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        lmwong, yes, you're right. They're doing functional, not structural, imaging, so they can't detect, for example, a tumor. Their pictures show not what the lungs look like but how much oxygen they pull in and absorb in different regions. The magnet strength in their machine is only up to about 100 gauss. The idea is not to displace X-rays or conventional MRI, but to build a cheap diagnostic for lung disease that might be simple enough to use in the doctor's office.

        The researchers did compare their work to nuclear medicine scans. They say their technique should give the same kind of information without exposing patients to radiation, and should take less time for imaging. However, as they caution, until they build up data from large clinical studies, this is somewhat speculative.
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  • Can I volunteer?
    lilyphoenix on 04/10/2008 at 5:05 PM
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    I'd gladly volunteer if it would help figure out why my asthma is worse lying down than anything. Do these people have an email?

    Edit: Even though the equipment is rather freaky looking.
    Rate this comment: 12345
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