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Shrinking sensors: A completed magnetometer built by NIST physicists is shown above. It consists of a small infrared laser (glued to a gold-coated plate), the cesium-filled cell, and a light detector.
Jim Yost; Courtesy of John Kitching
John Kitching's tiny magnetic-field sensors will take MRI where it's never gone before.
Magnetic fields are everywhere, from the human body to the metal in a buried land mine. Even molecules such as proteins generate their own distinctive magnetic fields. Both magnetic resonance imaging (MRI), which yields stunningly detailed images of the body, and nuclear magnetic resonance spectroscopy (NMR), which is used to study proteins and other compounds such as petroleum, rely on magnetic information. But the sensors currently used to detect these faint but significant magnetic fields all have disadvantages. Some are portable and cheap but not very sensitive; others are highly sensitive but stationary, expensive, and power-hungry.
Now John Kitching, a physicist at the National Institute of Standards and Technology in Boulder, CO, is developing tiny, low-power magnetic sensors almost as sensitive as their big, expensive counterparts. About the size of a fat grain of rice, the sensors are called atomic magnetometers. Kitching hopes that they will one day be incorporated into everything from portable MRI machines to faster and cheaper detectors for unexploded bombs.
The tiny sensors have three key components, stacked vertically on top of a silicon chip. An off-the-shelf infrared laser and an infrared photodetector sandwich a glass-and-silicon cube filled with vaporized cesium atoms. In the absence of a magnetic field, the laser light passes straight through the cesium atoms. In the presence of even very weak magnetic fields, though, the atoms' alignment changes, allowing them to absorb an amount of light proportional to the strength of the field. This change is picked up by the photodetector. "It's a simple configuration with extremely good sensitivity," Kitching says.
Atomic magnetometers have been around for about 50 years; most have large, sensitive vapor cells, about the size of soda cans, made using glassblowing techniques. The most sensitive of these can detect fields on the order of a femtotesla--about one-fifty-billionth the strength of Earth's magnetic field. Kitching's innovation was to shrink the vapor cell to a volume of only a few cubic millimeters, decreasing power usage while keeping performance comparable.
Working with five other physicists, Kitching makes the vapor cells using micromachining techniques. They begin by using a combination of lithography and chemical etching to punch square holes three millimeters across into a silicon wafer. Then they clamp the silicon to a slip of glass and create a bond using high heat and a voltage, turning the square hole into a topless box with a glass bottom.
Inside a vacuum chamber, they use a tiny glass syringe to fill the box with vaporized cesium atoms; then they seal the box with another slip of glass at high heat. (This must be done in a vacuum because cesium reacts vigorously with water and oxygen.) Next, the physicists mount the finished vapor cell on a chip, along with the infrared laser and the photodetector. They pass a current through thin conductive films on the top and bottom of the cell to produce heat, which keeps the cesium atoms vaporized.
Kitching currently builds magnetometers a few at a time in the lab, but he has designed them with bulk manufacturing in mind. Many copies of each component are carved out simultaneously from a single silicon wafer. Several wafers, each containing multiple copies of a different component, could be layered one on top of the other. Then the stack could be sliced into multiple magnetometers.
I'm far more interested in the potential for increased resolution of MRI using these sensors with the huge superconducting magnets of current medical MRI machines. If the resolution can be increased to the level of individual synaptic dimensions, then a complete structural snapshot of a working brain might be possible.
That would be very exciting! Unfortunately, it's likely that this type of magnetometer won't provide resolution below a few 100 microns, because of some size limitations, it'll be tough to bring it close to a sample.
There are some really neat magnetometers up and coming though that might be able to provide nm resolution for MRI, check out the NV magnetometer. Still hasn't been shown to get resolution of 1nm which is what you would need to image synapses, but still pretty cool.
Manufacturing in the United States is in trouble. That's bad news not just for the country's economy but for the future of innovation.
enantiomer2000
66 Comments
BCI anybody?
Could this be used as a brain machine interface at some point in the future? Current non-implantable ones just sense the electrical conductivity on the surface of the scalp, but this could allow for a much more robust brain computer interface. It would be very useful for anybody who wants to integrate their mind with their computers.
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Lord Skelos
10 Comments
Re: BCI anybody?
I'm with you all the way on that idea, but chech this out: if we were to make nanobots or nervous system implants that used this technology, we could: 1. Give the human body a new magnetic sense that could allows for new levels of communication and understanding, or 2. Equip nanobots with the ability to scan our body constantly as they flow through our bodies, and destroy any malevolent lifeforms or toxins they find on a much wider scale. Using this as the primary sense for nanobots would also allow them to be a billion times more useful than they are with just touch.
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