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March 2007

Synthetic Biology on Display

Researchers are fooling around with E. coli.

By Daniel Turner

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Researchers extracted phytochromes, photoreceptive proteins, from cyanobacteria (shown here) to enable E. coli to be photosynthetic.
Credit: Linda Nye
Multimedia
•  View the hack of the genes of E. coli bacteria.

Christopher Voigt and his research partners at the University of California, San Francisco, and the University of Texas at Austin hacked the genes of E. coli bacteria, making each altered cell photosensitive. (Voigt is a member of the current TR35, our annual list of 35 exceptional innovators under the age of 35. He and the others were featured in the September/October 2006 issue.) Their first application of the technology, shown in this slide show, was a lawn of bacteria that acts like a photographic plate: when exposed to red light, the lawn reproduces an image inscribed into a stencil held between it and the light source. But this isn't the goal of Voigt's research--it's just an example of the powerful possibilities raised by the young field of synthetic biology. The ability to precisely engineer and control micro­örganisms could lead to new bacterial factories that produce complex drugs or materials.

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March/April 2007

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Comments

  • Green Knowledge
    peterherb on 03/14/2007 at 10:43 PM
    Posts:
    1
    We believe that Green Knowledge must be free, free to improve all of our lives and to protect the Earth we are all sharing!

    Plant Extracts are actually the Ingredients extracted from Herbal Plants. They are really Green Products!

    Here is a big showroom of all kind of Plant Extracts: url=http://www.herbalextract.

    What do you think about it?
    Rate this comment: 12345
  • VERY SCARY
    VCRAGAIN on 04/09/2007 at 1:10 PM
    Posts:
    32
    Avg Rating:
    4/5
    I am rather concerned that this research could expose us to all sorts of unpredictable results - why E.coli ? arent there a myriad of non-pathogenic organisms to tinker with - isnt this a very risky area to tinker with at all ??
    Short of robots that turn around and start trying to control us, I think organisms that are
    modified and end up with characteristics that kill us all off is the next most ghastly idea - oh well I guess they will get controlled by the robots and live happily ever after - so why am i worrying  (:<)     
    please tell me I have been watching too many horror movies !!!    
    Rate this comment: 12345
    • Re: VERY SCARY
      brunascle on 04/09/2007 at 1:37 PM
      Technology Review TR Staff
      Web Developer
      Posts:
      69
      Avg Rating:
      4/5
      you have been watching too many horror movies !!!

      e. coli has been used in microbiology for a long time. from the all-knowing wikipedia:
      "Its structure is clear, and it makes for an excellent target for novice, intermediate, and advanced students of the life sciences.... The strains used in the laboratory have adapted themselves effectively to that environment, and are no longer as well adapted to life in the mammalian intestines as the wild type;"

      http://en.wikipedia.org/wiki/E_coli#Role_in_microbiology
      Rate this comment: 12345
    • Re: VERY SCARY
      gabrielg01 on 04/11/2007 at 4:47 PM
      Posts:
      270
      Avg Rating:
      3/5
      E.coli is not the scary monster it is made out to be.

      There are many strains of E.coli, and most of them are benign. In fact, there are several strains living in humans, and you can think of these benign strains as your microbial bodyguards. They compete with other potentially pathogenic strains, and keep their numbers low. If we didn't have benign bacteria living in us, we'd be overrun by the nasty ones.
      Rate this comment: 12345
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