Readme

Fund a 'Moonshot' for RNAi

  • March 2005
  • By TR Staff and Freelance Writers

Translating promising science into new therapies.

   

Amid the national debate over stem cells and therapeutic cloning, there's another biomedical technology that is showing increasing promise without the ethical conundrums. RNA interference (RNAi) is a natural regulatory process in which small, double-stranded RNA molecules turn off specific genes in a cell. Because RNAi is highly targeted and efficient, it has become a widely used tool for understanding what genes do and how they work. But its real payoff lies in new therapies -- and developing them will require a renewed commitment to funding and research.

Exploiting the properties of RNA molecules could yield more-effective drugs to fight cancer, HIV, influenza, and other diseases. Rather than blocking the effects of specific proteins, which is what conventional drugs do, an RNAi-based therapy could in theory stop the proteins from being made in the first place. Mark Kay, director of the Program in Human Gene Therapy at the Stanford University School of Medicine, calls RNAi "incredibly robust technology with incredible therapeutic potential" but cautions that it's in a "very new, very early stage."

 

To read the entire article you must log in:

Most of our content — all daily news, blogs, and videos — is free. Magazine stories are paid. To read this story, you must have a subscription or you must use a reading credit. Registration to Technology Review is free and entitles registrants to three free reading credits.

Username or REGISTER
Password  
   
 
Advertisement

MAGAZINE

Can We Build Tomorrow's Breakthroughs?

Manufacturing in the United States is in trouble. That's bad news not just for the country's economy but for the future of innovation.

Videos

Meet 2011 TR35 Winner Jesse Robbins

More

Advertisement

Technology Review Lists

TR50

Our list of the 50 most innovative companies, including the following:

Silver Spring Networks

Toyota

Siemens

Facebook

More

Advertisement

Facebook

Advertisement